ArticlePloS one2019
Marked reduction in fertility among African women with urogenital infections: A prospective cohort study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role of vulvovaginal candidiasis infection in infertility: systematic review and meta-analysis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Pooled it
- Doxycycline Prophylaxis to Prevent Sexually Transmitted Infections in Women.The New England journal of medicine · 2023Trial
- Candida albicans migrates itself from the vagina to the uterus and ovaries in estrogenized mice.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- The burden of visually diagnosed female genital schistosomiasis among women with infertility in the Volta Region of Ghana.Tropical medicine and health · 2025Article
- Trends in Prevalence of Yeast Species Associated With Urogenital Infection in Nsukka, Nigeria: An Overview of TrueInternational journal of microbiology · 2025Article
- Editorial Note: Marked reduction in fertility among African women with urogenital infections: A prospective cohort study.PloS one · 2025Article
- From Cure to Prevention: Doxycycline's Potential in Prophylaxis for Sexually Transmitted Infections.Antibiotics (Basel, Switzerland) · 2024Review
- Evaluation and optimization of the syndromic management of female genital tract infections in Nairobi, Kenya.BMC infectious diseases · 2023Article
- A New Phenotype inmBio · 2023Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is paucity of data on risk factors for reduced fertility in low-income countries.
objectiveTo investigate factors associated with fertility among women in rural north eastern Tanzania. SUBJECTS AND
methodsA cohort of 1248 non-pregnant women was followed with urine pregnancy testing every third month or more regularly if they reported a missed menstrual period. Pregnancy was confirmed with trans-abdominal ultrasound. Information regarding general health, socioeconomic status and obstetric-gynaecological history was collected. Factors associated with conceiving within 180 days were identified using multivariate logistic regression analyses.
resultsAmong the 1248 women, 736 were followed for 180 days and 209 of these had an ultrasound confirmed pregnancy. During the follow-up period, 169/736 women were diagnosed with urogenital infections, including suspected sexually transmitted or reproductive tract infections, urinary tract infection, and vaginal candidiasis. Urogenital infections were significantly associated with reduced odds of conceiving within 180 days (adjusted OR (AOR) 0.21, 95% CI 0.11-0.36). Being above 30 years of age was also negatively associated with odds of conceiving (AOR 0.45, 95% CI 0.26-0.77). In contrast, women who recently stopped using hormonal contraceptives (AOR 2.86, 95% CI 1.45-5.70) and women with low socioeconomic status (AOR 1.56, 95% CI 1.04-2.33) were significantly more likely to become pregnant within 180 days.
conclusionUrogenital infection seems to be a major health factor associated with reduced chances of conceiving. Considering the availability of effective treatment options for these diseases, public health authorities should increase awareness of diagnostic tools in settings with limited resources in order to improve fertility.
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