ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019
Larger nephron size, low nephron number, and nephrosclerosis on biopsy as predictors of kidney function after donating a kidney.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 48 citations in OpenAlex.
- Perirenal Adipose Tissue may be an Important Predictor of Adverse Kidney Outcomes in Living Kidney Donors.Kidney international reports · 2026Article
- Visceral Adipose Tissue Alters Podometrics and Renal Compensation After Uninephrectomy.Kidney international reports · 2026Article
- Chronic Changes on Kidney Histology by a Multiclass Artificial Intelligence Model.Kidney international reports · 2025Article
- Consequences of low estimated glomerular filtration rate either before or early after kidney donation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Characterization of arteriosclerosis based on computer-aided measurements of intra-arterial thickness.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Association of Implantation Biopsy Findings in Living Donor Kidneys With Donor and Recipient Outcomes.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Morphometric analysis of chronicity on kidney biopsy: a useful prognostic exercise.Clinical kidney journal · 2024Review
- The relationship of peritubular capillary density with glomerular volume and kidney function in living kidney donors.Journal of nephrology · 2023Article
- Changes in Glomerular Volume, Sclerosis, and Ischemia at 5 Years after Kidney Transplantation: Incidence and Correlation with Late Graft Failure.Journal of the American Society of Nephrology : JASN · 2023Article
- Long-term Medical Outcomes of Living Kidney Donors.Mayo Clinic proceedings · 2022Review
- Association between expanded criteria for living kidney donors and renal biopsy findings.Journal of nephrology · 2022Article
- Kidney glomerular filtration rate plasticity after transplantation.Clinical kidney journal · 2022Article
- Clinical and Kidney Structural Characteristics of Living Kidney Donors With Nephrolithiasis and Their Long-term Outcomes.Transplantation direct · 2022Article
- Renal function outcomes and kidney biopsy features of living kidney donors with hypertension.Clinical transplantation · 2021Article
- Nephron-deficient HSRA rats exhibit renal injury with age but have limited renal damage from streptozotocin-induced hyperglycemia.American journal of physiology. Renal physiology · 2021Article
- Impact of high body mass index on allograft outcomes in kidney transplant recipients with presensitization to human leukocyte antigen.Kidney research and clinical practice · 2021Article
- Nephron number and its determinants: a 2020 update.Pediatric nephrology (Berlin, Germany) · 2021Article
- Larger Nephron Size and Nephrosclerosis Predict Progressive CKD and Mortality after Radical Nephrectomy for Tumor and Independent of Kidney Function.Journal of the American Society of Nephrology : JASN · 2020Article
- Kidney Structural Features from Living Donors Predict Graft Failure in the Recipient.Journal of the American Society of Nephrology : JASN · 2020Article
- Whole genome sequencing and novel candidate genes for CAKUT and altered nephrogenesis in the HSRA rat.Physiological genomics · 2020Article
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11 authors at 4 institutions in 1 country.
Funding
Abstract
It is unclear whether structural findings in the kidneys of living kidney donors predict postdonation kidney function. We studied living kidney donors who had a kidney biopsy during donation. Nephron size was measured by glomerular volume, cortex volume per glomerulus, and mean cross-sectional tubular area. Age-specific thresholds were defined for low nephron number (calculated from CT and biopsy measures) and nephrosclerosis (global glomerulosclerosis, interstitial fibrosis/tubular atrophy, and arteriosclerosis). These structural measures were assessed as predictors of postdonation measured GFR, 24-hour urine albumin, and hypertension. Analyses were adjusted for baseline age, gender, body mass index, systolic and diastolic blood pressure, hypertension, measured GFR, urine albumin, living related donor status, and time since donation. Of 2673 donors, 1334 returned for a follow-up visit at a median 4.4 months after donation, with measured GFR <60 mL/min/1.73 m
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