ArticleThe Journal of infectious diseases2019
Photoinactivation of Neisseria gonorrhoeae: A Paradigm-Changing Approach for Combating Antibiotic-Resistant Gonococcal Infection.
Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The potential role of violet-blue light to preventing hospital acquired infections: a systematic review.Frontiers in public health · 2024Pooled it
- Milestones in the Elucidation of Heme Biosynthesis.Chemical reviews · 2026Review
- Selective bactericidal efficacy of 465-nm blue light phototherapy against standard and canine wound pathogens: AnVeterinary world · 2025Article
- Antimicrobial effect of blue light on antibiotic-sensitive and drug-resistant Escherichia coli: a novel isotropic optical fibre.Access microbiology · 2025Article
- Natural Phytochemical and Visible Light at Different Wavelengths Show Synergistic Antibacterial Activity againstPharmaceutics · 2024Article
- Addressing Sexually Transmitted Infections Due toMicroorganisms · 2024Review
- Innovative Phosphorene Nanoplatform for Light Antimicrobial Therapy.Pharmaceutics · 2023Review
- Emerging threat of antimicrobial resistance in Neisseria gonorrhoeae: pathogenesis, treatment challenges, and potential for vaccine development.Archives of microbiology · 2023Review
- Oregano Oil and Harmless Blue Light to Synergistically Inactivate Multidrug-ResistantFrontiers in microbiology · 2022Article
- Antimicrobial blue light: A 'Magic Bullet' for the 21st century and beyond?Advanced drug delivery reviews · 2022Review
- Antimicrobial Blue Light for Prevention and Treatment of Highly InvasiveFrontiers in microbiology · 2022Article
- The microbicidal potential of visible blue light in clinical medicine and public health.Frontiers in medicine · 2022Review
- Effective Treatment of Cutaneous Mold Infections by Antimicrobial Blue Light That Is Potentiated by Quinine.The Journal of infectious diseases · 2021Article
- Pulsed blue light inactivates two strains of human coronavirus.Journal of photochemistry and photobiology. B, Biology · 2021Article
- Review
- Potentiated antimicrobial blue light killing of methicillin resistant Staphylococcus aureus by pyocyanin.Journal of photochemistry and photobiology. B, Biology · 2021Article
- An extended logistic model of photodynamic inactivation for various levels of irradiance using the example of Streptococcus agalactiae.Scientific reports · 2020Article
- Antimicrobial Blue Light Inactivation of Microbial Isolates in Biofilms.Lasers in surgery and medicine · 2020Article
- Photoinactivation of Moraxella catarrhalis Using 405-nm Blue Light: Implications for the Treatment of Otitis Media.Photochemistry and photobiology · 2020Article
- TheFrontiers in microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Antimicrobial resistance in Neisseria gonorrhoeae is a major issue of public health, and there is a critical need for the development of new antigonococcal strategies. In this study, we investigated the effectiveness of antimicrobial blue light (aBL; wavelength, 405 nm), an innovative nonpharmacological approach, for the inactivation of N. gonorrhoeae. Our findings indicated that aBL preferentially inactivated N. gonorrhoeae, including antibiotic-resistant strains, over human vaginal epithelial cells in vitro. Furthermore, no aBL-induced genotoxicity to the vaginal epithelial cells was observed at the radiant exposure used to inactivate N. gonorrhoeae. aBL also effectively inactivated N. gonorrhoeae that had attached to and invaded into the vaginal epithelial cells in their cocultures. No gonococcal resistance to aBL developed after 15 successive cycles of inactivation induced by subtherapeutic exposure to aBL. Endogenous aBL-activatable photosensitizing porphyrins in N. gonorrhoeae were identified and quantified using ultraperformance liquid chromatography, with coproporphyrin being the most abundant species in all N. gonorrhoeae strains studied. Singlet oxygen was involved in aBL inactivation of N. gonorrhoeae. Together, these findings show that aBL represents a potential potent treatment for antibiotic-resistant gonococcal infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.