ArticleThe Journal of infectious diseases2019
Serum Metabolome Is Associated With the Nasopharyngeal Microbiota and Disease Severity Among Infants With Bronchiolitis.
Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploring the microbial landscape of the nasopharynx in children: a systematic review of studies using next generation sequencing.Frontiers in microbiomes · 2023Pooled it
- The Commensal Microbiota and Viral Infection: A Comprehensive Review.Frontiers in immunology · 2019Pooled it
- Longitudinal Analysis of Nasopharyngeal Microbial Risk Markers for Fatal Acute Febrile Illness in a Zambian Birth Cohort.The Journal of infectious diseases · 2025Article
- Integrated nasopharyngeal airway metagenome and asthma genetic risk endotyping of severe bronchiolitis in infancy and risk of childhood asthma.The European respiratory journal · 2024Article
- Effect of respiratory microflorae colonization on short and long-time outcomes of respiratory syncytial virus infection in children: A scoping review.Pediatric discovery · 2024Review
- Nasal microRNA signatures for disease severity in infants with respiratory syncytial virus bronchiolitis: a multicentre prospective study.BMJ open respiratory research · 2024Article
- Influence of Mycobiota in the Nasopharyngeal Tract of COVID-19 Patients.Microorganisms · 2024Article
- Respiratory Virus-Specific Nasopharyngeal Lipidome Signatures and Severity in Infants With Bronchiolitis: A Prospective Multicenter Study.The Journal of infectious diseases · 2023Article
- Analysis of nasopharyngeal microbiome patterns in Zambian infants with fatal acute febrile illness.bioRxiv : the preprint server for biology · 2023Article
- Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study.Nature communications · 2023Article
- Metabolomics in pediatric lower respiratory tract infections and sepsis: a literature review.Pediatric research · 2023Review
- Dynamics of nasopharyngeal tract phageome and association with disease severity and age of patients during three waves of COVID-19.Journal of medical virology · 2022Article
- Article
- Nasopharyngeal airway dual-transcriptome of infants with severe bronchiolitis and risk of childhood asthma: A multicenter prospective study.The Journal of allergy and clinical immunology · 2022Article
- Association of Nasopharyngeal and Serum Glutathione Metabolism with Bronchiolitis Severity and Asthma Risk: A Prospective Multicenter Cohort Study.Metabolites · 2022Article
- Serum periostin among infants with severe bronchiolitis and risk of developing asthma: A prospective multicenter cohort study.Allergy · 2022Article
- Article
- Metabolome subtyping of severe bronchiolitis in infancy and risk of childhood asthma.The Journal of allergy and clinical immunology · 2022Article
- Integrative genetics-metabolomics analysis of infant bronchiolitis-childhood asthma link: A multicenter prospective study.Frontiers in immunology · 2022Article
- Serum Soluble Receptor for Advanced Glycation End Products in Infants With Bronchiolitis: Associations With Acute Severity and Recurrent Wheeze.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundEmerging evidence suggests relationships between the nasopharyngeal metabolome and both the microbiota and severity of bronchiolitis. However, the influence of host systemic metabolism on disease pathobiology remains unclear. We aimed to examine metabolome profiles and their association with more-severe disease, defined by use of positive pressure ventilation (PPV), in infants hospitalized for bronchiolitis.
methodsIn 140 infants with bronchiolitis, metabolomic profiling was performed on serum; samples from 70 were in a training data set, and samples from 70 were in an independent test data set. We also profiled the nasopharyngeal airway microbiota and examined its association with the serum metabolites.
resultsSerum metabolome profiles differed by bronchiolitis severity (P < .001). In total, 20 metabolites in the training data set were significantly associated with the risk of PPV, of which 18 remained significant following adjustment for confounders (false-discovery rate [FDR], < 0.10). Phosphatidylcholine metabolites were associated with higher risks of PPV use, while metabolites from the plasmalogen subpathway were associated with lower risks. The test data set validated these findings (FDR < 0.05). Streptococcus abundance was positively associated with metabolites that are associated with higher risks of PPV.
conclusionsSerum metabolomic signatures were associated with both the nasopharyngeal microbiota and the severity of bronchiolitis. Our findings advance research into the complex interrelations between the airway microbiome, host systemic response, and pathobiology of bronchiolitis.
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