Evidence map›Paper›PMID 30628812›Full record

ArticleExperimental and clinical psychopharmacology2019

Effects of multisensory stop signals on alcohol-induced disinhibition in adults with ADHD.

Alexandra R D'Agostino, Michael J Wesley, Jaime Brown, Mark T Fillmore

Open access · hybridAbstract read
In one paragraph

Article in Experimental and clinical psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alexandra R D'AgostinoDepartment of Psychology, College of Arts and Sciences, University of Kentucky.
Michael J WesleyDepartment of Behavioral Science, College of Medicine, University of Kentucky.
Jaime BrownDepartment of Psychology, College of Arts and Sciences.
Mark T FillmoreDepartment of Psychology, College of Arts and Sciences.
University of Kentucky · US

Funding

Behavioral Dysregulation and Alcohol Sensitivity in Risky DriversR01AA021722 · NIAAA · UNIVERSITY OF KENTUCKY · PI FILLMORE, MARK T · 2013 to 2016
$1.3M
Neural Mechanisms of Cannabinoid-Impaired Decision-Making in Emerging AdultsK01DA043652 · NIDA · UNIVERSITY OF KENTUCKY · PI WESLEY, MICHAEL J · 2018 to 2022
$792k
National Institute on Alcohol Abuse and AlcoholismNIAAA NIH HHS R01 AA021722NIDA NIH HHS K01 DA043652
6 · The paper itself

Abstract

Multisensory environments facilitate behavioral functioning in humans. The redundant signal effect (RSE) refers to the observation that individuals respond more quickly to stimuli when information is presented as multisensory, redundant stimuli (e.g., aurally and visually) rather than as a single stimulus presented to either modality alone. RSE appears to be because of specialized multisensory neurons in the superior colliculus and association cortex that allow intersensory coactivation between the visual and auditory channels. Our studies show that the disinhibiting effects of alcohol are attenuated when stop signals are multisensory (e.g., Visual + Auditory stop signals) versus unisensory (Roberts, Monem, & Fillmore, 2016). The present study expanded on this research to test the degree to which multisensory stop signals could also attenuate the disinhibiting effects of alcohol in those with attention-deficit hyperactivity disorder (ADHD), a clinical population characterized by poor impulse control. The study compared young adults with ADHD (n = 22) with healthy controls (n = 22) and examined the acute impairing effect of alcohol on response inhibition to stop signals that were presented as a unisensory (visual) stimulus or a multisensory (Visual + Auditory) stimulus. For controls, results showed alcohol impaired response inhibition to unisensory stop signals but not to multisensory stop signals. Response inhibition of those with ADHD was impaired by alcohol regardless of whether stop signals were unisensory or multisensory. The failure of multisensory stimuli to attenuate alcohol impairment in those with ADHD highlights a specific vulnerability that could account for heightened sensitivity to the disruptive effects of alcohol. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Indexed as

Impulsive BehaviorAdultAttention Deficit Disorder with HyperactivityCase-Control StudiesEthanolFemaleHumansMalePhotic StimulationReaction TimeVisual PerceptionYoung AdultEthanol

Identifiers

PMID30628812
PMCPMC6538486
OpenAlexW2910286438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.