ArticleJournal of child neurology2019
Severe Herpes Zoster Following Varicella Vaccination in Immunocompetent Young Children.
Article in Journal of child neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Serious neurological adverse events in immunocompetent children and adolescents caused by viral reactivation in the years following varicella vaccination.Reviews in medical virology · 2024Pooled it
- Whole-genome sequence of a varicella-zoster strain from an immunocompetent pediatric patient with severe herpes zoster.Microbiology resource announcements · 2026Article
- Severe Disseminated Varicella Zoster in an Immunocompetent Adolescent: A Case Report.Clinical medicine insights. Pediatrics · 2026Article
- A Stepwise Household Transmission of Vaccine-Strain Varicella-Zoster Virus Resulting in Neonatal Varicella.Infection & chemotherapy · 2026Article
- Article
- Contemporaneous varicella and zoster or disseminated zoster? A diagnostic challenge in an HIV-positive child.Southern African journal of infectious diseases · 2026Article
- Perspectives on the History and Epidemiology of the Varicella Virus Vaccine and Future Challenges.Pathogens (Basel, Switzerland) · 2025Review
- Article
- Insights into pathologic mechanisms occurring during serious adverse events following live zoster vaccination.Journal of virology · 2025Review
- Recurrent vaccine-strain varicella zoster virus reactivation in a child with acute lymphatic leukemia.IDCases · 2025Article
- Pediatric herpes zoster: should I be concerned for immunodeficiency? A review.Frontiers in pediatrics · 2025Review
- Genotype of Varicella-zoster virus isolated in Jiangsu, China.Virology journal · 2024Article
- Herpes Zoster Burden of Disease and Clinical Management in Turkey: A Comprehensive Literature Review.Infectious diseases and therapy · 2023Review
- The Association between Varicella Vaccination and Herpes Zoster in Children: A Semi-National Retrospective Study.Journal of clinical medicine · 2023Article
- Meningitis caused by the varicella vaccine virus in 17 immunized children and adolescents from the United States, Europe, and Japan.Annals of the Child Neurology Society · 2023Review
- Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study.Biomedicines · 2023Article
- Common Features Between Stroke Following Varicella in Children and Stroke Following Herpes Zoster in Adults : Varicella-Zoster Virus in Trigeminal Ganglion.Current topics in microbiology and immunology · 2023Review
- Signaling COVID-19 Vaccine Adverse Events.Drug safety · 2022Article
- Zoster Meningitis in an Immunocompetent Child after COVID-19 Vaccination, California, USA.Emerging infectious diseases · 2022Article
- Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections.Frontiers in neurology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Varicella vaccination is now virtually universal in North America, as well as in some European and Asian countries. Since varicella vaccine is a live attenuated virus, the virus replicates in the skin after administration and can travel via sensory nerves or viremia to become latent in the dorsal root ganglia. In some immunized children, virus reactivates within a few months to a few years to cause the dermatomal exanthem known as herpes zoster (shingles). Herpes zoster caused by vaccine virus often reactivates within the same dermatome as the site of the original varicella vaccine injection. We present evidence that occasional cases of herpes zoster following varicella vaccination in immunocompetent children can be as severe as herpes zoster following wild-type varicella. Analysis of the virus in one case disclosed that the vaccine virus causing herpes zoster was a wild-type variant with a mutation in ORF0. With regard to dermatomal localization of the viral eruption, we predict that herpes zoster of the lumbar dermatomes in children is likely to be caused by vaccine virus, because herpes zoster in those dermatomes is rare in children after wild-type varicella. One of the children with herpes zoster subsequently developed asthma, a known risk factor for herpes zoster, but none of the children had an autoimmune disease. Although postherpetic neuralgia is exceedingly rare, children who develop herpes zoster following varicella vaccination are at risk (albeit low) of developing meningoencephalitis and should be carefully observed for a few weeks.
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