Evidence map›Paper›PMID 30628490›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

Lethal avian influenza A (H5N1) virus replicates in pontomedullary chemosensitive neurons and depresses hypercapnic ventilatory response in mice.

Jianguo Zhuang, Na Zang, Chunyan Ye, Fadi Xu

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jianguo ZhuangPathophysiology Program, Lovelace Respiratory Research Institute , Albuquerque, New Mexico.
Na ZangPathophysiology Program, Lovelace Respiratory Research Institute , Albuquerque, New Mexico.
Chunyan YePathophysiology Program, Lovelace Respiratory Research Institute , Albuquerque, New Mexico.
Fadi XuPathophysiology Program, Lovelace Respiratory Research Institute , Albuquerque, New Mexico.
Lovelace Respiratory Research Institute · US

Funding

Lethal H5N1 Virus Infection and Respiratory DisordersR01HL119683 · NHLBI · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI XU, FADI · 2013 to 2016
$2.1M
NHLBI NIH HHS R01 HL119683
6 · The paper itself

Abstract

The highly pathogenic H5N1 (HK483) viral infection causes a depressed hypercapnic ventilatory response (dHCVR, 20%↓) at 2 days postinfection (dpi) and death at 7 dpi in mice, but the relevant mechanisms are not fully understood. Glomus cells in the carotid body and catecholaminergic neurons in locus coeruleus (LC), neurokinin 1 receptor (NK

Indexed as

AnimalsBirdsFemaleHumansHypercapniaInfluenza A virusInfluenza A Virus, H5N1 SubtypeInfluenza, HumanInfluenza in BirdsMice, Inbred BALB CNeuronsReceptors, Neurokinin-1Receptors, Neurokinin-1CO chemoreflexrespiratory failureviral infection

Identifiers

PMID30628490
PMCPMC6459289
OpenAlexW2910148737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.