Evidence map›Paper›PMID 30628488›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury.

Yi Jin, Yusen Liu, Leif D Nelin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Cyclooxygenase-2 deficiency attenuates lipopolysaccharide-induced inflammation, apoptosis, and acute lung injury in adult mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yi JinPulmonary Hypertension Group, Center for Perinatal Research, Research Institute at Nationwide Children's Hospital, and Department of Pediatrics, The Ohio State University , Columbus, Ohio.
Yusen LiuPulmonary Hypertension Group, Center for Perinatal Research, Research Institute at Nationwide Children's Hospital, and Department of Pediatrics, The Ohio State University , Columbus, Ohio.
Leif D NelinPulmonary Hypertension Group, Center for Perinatal Research, Research Institute at Nationwide Children's Hospital, and Department of Pediatrics, The Ohio State University , Columbus, Ohio.
The Ohio State University · USNationwide Children's Hospital · US

Funding

Regulation and Function of Mkp-1 During Sepsis.R01AI124029 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2017 to 2021
$1.9M
Mkp-1 suppresses immune checkpoint protein PD-L1 to prevent sepsis-associated immune dysfunction and mortalityR21AI142885 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2019 to 2020
$418k
NIAID NIH HHS R01 AI124029NIAID NIH HHS R21 AI142885
6 · The paper itself

Abstract

The pathology of acute lung injury (ALI) involves inducible nitric oxide (NO) synthase (iNOS)-derived NO-induced apoptosis of pulmonary endothelial cells. In vitro, iNOS-derived NO production has been shown to depend on the uptake of l-arginine by the cationic amino acid transporters (CAT). To test the hypothesis that mice deficient in CAT-2 ( slc7a2

Indexed as

Acute Lung InjuryAmino Acid Transport Systems, BasicAnimalsCationic Amino Acid Transporter 1Cyclooxygenase 2Disease Models, AnimalFemaleHyperoxiaInterleukin-6MaleMiceMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIRNA, MessengerAmino Acid Transport Systems, BasicCationic Amino Acid Transporter 1Cyclooxygenase 2Interleukin-6interleukin-6, mouseNitric Oxide Synthase Type IINitric Oxide Synthase Type IIINos2 protein, mouseNos3 protein, mousePtgs2 protein, mouseRNA, MessengerSlc7a1 protein, mouseSlc7a2 protein, mouseacute lung injurycationic amino acid transportersinducible nitric oxide synthaseslc7a2 knockout mice

Identifiers

PMID30628488
PMCPMC6842872
OpenAlexW2908746587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.