Evidence map›Paper›PMID 30628485›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

Apoptosis signal-regulating kinase-1 promotes inflammasome priming in macrophages.

Camille N Immanuel, Bin Teng, Brittany Dong, Elizabeth M Gordon, Joseph A Kennedy, Charlean Luellen, Andreas Schwingshackl, Stephania A Cormier, Elizabeth A Fitzpatrick, Christopher M Waters

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. ER-to-lysosome CaeLife · 2024
    Article
  3. Two-pore potassium channel TREK-1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  4. Article
  5. The Multifaceted Roles of Macrophages in NAFLD Pathogenesis.Cellular and molecular gastroenterology and hepatology · 2023
    Review
  6. ASK1 Regulates Bleomycin-induced Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Camille N ImmanuelDivision of Pediatric Critical Care, Department of Pediatrics, Children's Foundation Research Institute at Le Bonheur Children's Hospital, University of Tennessee Health Sciences , Memphis, Tennessee.
Bin TengDepartment of Physiology, University of Tennessee Health Science Center , Memphis, Tennessee.
Brittany DongDepartment of Physiology, University of Kentucky , Lexington, Kentucky.
Elizabeth M GordonDepartment of Physiology, University of Kentucky , Lexington, Kentucky.
Joseph A KennedyDepartment of Physiology, University of Tennessee Health Science Center , Memphis, Tennessee.
Charlean LuellenDepartment of Physiology, University of Tennessee Health Science Center , Memphis, Tennessee.
Andreas SchwingshacklDepartment of Pediatrics, Mattel Children's Hospital at the University of California , Los Angeles, California.
Stephania A CormierDepartment of Biological Sciences, Louisiana State University , Baton Rouge, Louisiana.
Elizabeth A FitzpatrickDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center , Memphis, Tennessee.
Christopher M WatersDepartment of Physiology, University of Kentucky , Lexington, Kentucky.
University of Kentucky · USUniversity of Tennessee Health Science Center · USLouisiana State University · USMattel Children's Hospital · US

Funding

Role of microbiota in increased influenza severity due to particulate matter exposureP42ES013648 · NIEHS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI SPRUNGER, PHILLIP · 2009 to 2024
$27.6M
The Role of IL4R Alpha in Neonatal RSV ImmunopathologyR01AI090059 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CORMIER, STEPHANIA A · 2011 to 2025
$6.7M
Combustion Generated PM0.1 and Predisposition to AsthmaR01ES015050 · NIEHS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CORMIER, STEPHANIA A · 2006 to 2022
$4.6M
ASK1 and Ventilator-Induced Lung InjuryR01HL131526 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WATERS, CHRISTOPHER M · 2017 to 2020
$1.7M
CXCR4 signaling in lung epithelial repairR01HL123540 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WATERS, CHRISTOPHER M · 2014 to 2017
$1.5M
The Role of 2-Pore Domain Potassium Channels in Acute Lung Injury.K08HL118118 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SCHWINGSHACKL, ANDREAS · 2014 to 2018
$792k
NHLBI NIH HHS K08 HL118118NHLBI NIH HHS R01 HL123540NHLBI NIH HHS R01 HL131526NIAID NIH HHS R01 AI090059NIEHS NIH HHS P42 ES013648NIEHS NIH HHS R01 ES015050
6 · The paper itself

Abstract

We previously showed that mice deficient in apoptosis signal-regulating kinase-1 (ASK1) were partially protected against ventilator-induced lung injury. Because ASK1 can promote both cell death and inflammation, we hypothesized that ASK1 activation regulates inflammasome-mediated inflammation. Mice deficient in ASK1 expression (ASK1

Indexed as

AnimalsApoptosisCarrier ProteinsCell LineInflammasomesInflammationLipopolysaccharidesMacrophagesMAP Kinase Kinase Kinase 5Mice, Inbred C57BLMice, KnockoutNeutrophil InfiltrationSignal TransductionCarrier ProteinsInflammasomesLipopolysaccharidesMap3k5 protein, mouseMAP Kinase Kinase Kinase 5acute respiratory distress syndromeapoptosis signal regulating kinase-1LPS priminglung inflammation

Identifiers

PMID30628485
PMCPMC6459294
OpenAlexW2909521211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.