ArticleMikrochimica acta2019
Detection of microRNA using a polydopamine mediated bimetallic SERS substrate and a re-circulated enzymatic amplification system.
Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Switching on Versatility: Recent Advances in Switchable Plasmonic Nanostructures.Small science · 2023Article
- The Convenience of Polydopamine in Designing SERS Biosensors with a Sustainable Prospect for Medical Application.Sensors (Basel, Switzerland) · 2023Review
- Target-triggered configuration change of DNA tetrahedron for SERS assay of microRNA 122.Mikrochimica acta · 2020Article
- Arrayed nanopore silver thin films for surface-enhanced Raman scattering.RSC advances · 2020Article
- Competitive aptasensor with gold nanoparticle dimers and magnetite nanoparticles for SERS-based determination of thrombin.Mikrochimica acta · 2019Article
- Fluorometric determination of microRNA by using target-triggered cascade signal amplification and DNA-templated silver nanoclusters.Mikrochimica acta · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
A surface-enhanced Raman scattering (SERS) method is described for the determination of microRNA that is associated with various forms of cancer. The substrate consists of functionalized gold-silver bimetallic structure, and the sensitivity is strongly enhanced by making use of a re-circulated enzymatic amplification system (REAS). Poly-dopamine acts as both a reductant and a protective of the substrates. It was employed to link the gold core and silver satellite. The unique "hot spots" consisting of a Au@PDA@Ag nanocomposite improve the Raman signal and sensitivity. The reductive feature of PDA can prevent the susceptible oxidation of metallic silver to maintain the high Raman activity. To improve the sensitivity of the assays, a re-circulated enzymatic amplification system was developed in which the nicking endonuclease triggers the nucleic acid reaction system to enter an amplified cycle. By integrating the bimetallic nanosubstrate and magnetic separation into the REAS, microRNA can be detected by SERS (best at the Raman band of 1586 cm
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