Evidence map›Paper›PMID 30627823›Full record

ArticleMolecular and cellular pediatrics2019

KUNO-Kids birth cohort study: rationale, design, and cohort description.

Susanne Brandstetter, Antoaneta A Toncheva, Jakob Niggel, Christine Wolff, Silvia Gran, Birgit Seelbach-Göbel, Christian Apfelbacher, Michael Melter, Michael Kabesch, KUNO-Kids study group

Abstract read
In one paragraph

Article in Molecular and cellular pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Influence of mode of delivery on neonatal QTc.Journal of perinatology : official journal of the California Perinatal Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Susanne BrandstetterUniversity Children's Hospital Regensburg (KUNO-Clinics), University of Regensburg, Clinic St. Hedwig, Steinmetzstr. 1-3, 93049, Regensburg, Germany. susanne.brandstetter@ukr.de.ORCID http://orcid.org/0000-0002-7021-8895
Antoaneta A TonchevaUniversity Children's Hospital Regensburg (KUNO-Clinics), University of Regensburg, Clinic St. Hedwig, Steinmetzstr. 1-3, 93049, Regensburg, Germany.
Jakob NiggelUniversity Children's Hospital Regensburg (KUNO-Clinics), University of Regensburg, Clinic St. Hedwig, Steinmetzstr. 1-3, 93049, Regensburg, Germany.
Christine WolffUniversity Children's Hospital Regensburg (KUNO-Clinics), University of Regensburg, Clinic St. Hedwig, Steinmetzstr. 1-3, 93049, Regensburg, Germany.
Silvia GranUniversity Children's Hospital Regensburg (KUNO-Clinics), University of Regensburg, Clinic St. Hedwig, Steinmetzstr. 1-3, 93049, Regensburg, Germany.
Birgit Seelbach-GöbelClinic of Obstetrics and Gynecology St. Hedwig, University of Regensburg, Regensburg, Germany.
Christian ApfelbacherMedical Sociology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Michael MelterUniversity Children's Hospital Regensburg (KUNO-Clinics), University of Regensburg, Clinic St. Hedwig, Steinmetzstr. 1-3, 93049, Regensburg, Germany.
Michael KabeschUniversity Children's Hospital Regensburg (KUNO-Clinics), University of Regensburg, Clinic St. Hedwig, Steinmetzstr. 1-3, 93049, Regensburg, Germany.
KUNO-Kids study group

Funding

Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie (DE) SYSINFLAME: 01ZX1306EEU HEALS:603964
6 · The paper itself

Abstract

backgroundBirth cohort studies can contribute substantially to the understanding of health and disease - in childhood and over the life course. The KUNO-Kids birth cohort study was established to investigate various aspects of child health, using novel omics technologies in a systems medicine approach.

resultsAfter 3 years of recruitment, 2515 infants and their families have joined the study. Parents with higher education are overrepresented as in many other birth cohorts and are more likely to complete follow-up assessments via self-report questionnaires. The vast majority of participants consented to clinical examinations of their child and to the non-invasive collection of diverse biosamples, which were processed specifically for their integrated use in omics technology covering genomics, epigenomics, transcriptomics, metabolomics, and microbiome analyses of the skin, oral cavity, and stool.

conclusionsThe data and diverse biomaterial collected in the KUNO-Kids birth cohort study will provide extensive opportunities for investigating child health and its determinants in a holistic approach. The combination of a broad range of research questions in one study will allow for a cost-effective use of biomaterial and omics results and for a comprehensive analysis of biological and social determinants of health and disease. Aiming for low attrition and ensuring participants' long-term commitment will be crucial to fully exploit the potential of the study.

Indexed as

Birth cohortChild healthOmicsParticipationStudy design

Identifiers

PMID30627823
PMCPMC6326917

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.