ReviewAnnals of intensive care2019
Weaning failure of cardiovascular origin: how to suspect, detect and treat-a review of the literature.
Review in Annals of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 70 citations in OpenAlex.
- The effects of positive end-expiratory pressure on cardiac function: a comparative echocardiography-conductance catheter study.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Trial
- Predictors of delayed extubation post-coronary artery bypass graft and its relationship with length of stay and in-hospital mortality in Jordan.Acute and critical care · 2026Article
- Modified Venous Excess Ultrasound (mVExUS) in the Prediction of Ventilator Weaning Failure: a Cohort Study.POCUS journal · 2026Article
- Cardiac rupture due to Takotsubo syndrome complicated by a myocardial bridge: a case series.European heart journal. Case reports · 2026Article
- The diaphragm-intercostal index for predicting weaning failure in mechanically ventilated patients: a prospective cohort study.Frontiers in medicine · 2026Article
- Thoracic fluid content by electrical cardiometry versus diaphragmatic excursion by ultrasound for the prediction of weaning success in patients with lung congestion.Acute and critical care · 2025Article
- Incidence and outcomes of extubation failure in mechanically ventilated patients with cirrhosis: a post-hoc analysis of a prospective multicenter study.Annals of intensive care · 2025Article
- Rescue percutaneous transluminal septal myocardial ablation for difficult ventilator weaning in drug-resistant hypertrophic obstructive cardiomyopathy: a case report.European heart journal. Case reports · 2025Article
- Prediction of weaning outcomes from mechanical ventilation in critically ill patients based on the combination of ultrasound parameters of the heart, lung, and diaphragm: a prospective observational cohort study.Quantitative imaging in medicine and surgery · 2025Article
- Incidence and risk factors of weaning-induced pulmonary oedema: results from a multicentre, observational study.Critical care (London, England) · 2025Observational
- Factors influencing weaning success from mechanical ventilation in Emergency department patients with acute respiratory failure.American journal of translational research · 2025Article
- Comparison of Landiolol and Esmolol on Haemodynamic Responses During Weaning of Intensive Care Unit Patients with Reduced Ejection Fraction after Vascular Surgery.Cardiac failure review · 2025Article
- Navigating Heart-Lung Interactions in Mechanical Ventilation: Pathophysiology, Diagnosis, and Advanced Management Strategies in Acute Respiratory Distress Syndrome and Beyond.Journal of clinical medicine · 2024Article
- Hemodynamic monitoring during weaning from mechanical ventilation in critically ill pediatric patients: a prospective observational study.BMC pediatrics · 2024Observational
- The Value of Ischemic Cardiac Biomarkers to Predict Spontaneous Breathing Trial or Extubation Failure: A Systematic Review.Journal of clinical medicine · 2024Review
- Combined cardiac, lung, and diaphragm ultrasound for predicting weaning failure during spontaneous breathing trial.Annals of intensive care · 2024Article
- Right ventricular free wall longitudinal strain during weaning from mechanical ventilation using high-flow or conventional oxygen treatment: a pilot study.The ultrasound journal · 2024Article
- The Role of Ultrasonography in the Process of Weaning from Mechanical Ventilation in Critically Ill Patients.Diagnostics (Basel, Switzerland) · 2024Review
- A Review of Prolonged Mechanical Ventilation in Pediatric Cardiac Surgery Patients: Risk Factors and Implications.Journal of multidisciplinary healthcare · 2024Review
- B-lines by lung ultrasound as a predictor of re-intubation in mechanically ventilated patients with heart failure.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among the multiple causes of weaning failure from mechanical ventilation, cardiovascular dysfunction is increasingly recognized as a quite frequent cause that can be treated successfully. In this review, we summarize the contemporary evidence of the most important clinical and diagnostic aspects of weaning failure of cardiovascular origin with special focus on treatment. Pathophysiological mechanisms are complex and mainly include increase in right and left ventricular preload and afterload and potentially induce myocardial ischemia. Patients at risk include those with preexisting cardiopulmonary disease either known or suspected. Clinically, cardiovascular etiology as a predominant cause or a contributor to weaning failure, though critical for early diagnosis and intervention, may be difficult to be recognized and distinguished from noncardiac causes suggesting the need of high suspicion. A cardiovascular diagnostic workup including bedside echocardiography, lung ultrasound, electrocardiogram and biomarkers of cardiovascular dysfunction or other adjunct techniques and, in selected cases, right heart catheterization and/or coronary angiography, should be obtained to confirm the diagnosis. Official clinical practice guidelines that address treatment of a confirmed weaning-induced cardiovascular dysfunction do not exist. As the etiologies of weaning-induced cardiovascular dysfunction are diverse, principles of management depend on the individual pathophysiological mechanisms, including preload optimization by fluid removal, guided by B-type natriuretic peptide measurement, nitrates administration in excessive afterload and/or myocardial ischemia, contractility improvement in severe systolic dysfunction as well as other rational treatment in specific indications in order to lead to successful weaning from mechanical ventilation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.