ArticleLab on a chip2019
Parahydrogen based NMR hyperpolarisation goes micro: an alveolus for small molecule chemosensing.
Article in Lab on a chip, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- Development of a fully automated workstation for conducting routine SABRE hyperpolarization.Scientific reports · 2024Article
- Multinuclear 1D and 2D NMR withNature communications · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents.International journal of molecular sciences · 2023Article
- Sensitive, Efficient and Portable Analysis of Molecular Exchange Processes by Hyperpolarized Ultrafast NMR.Angewandte Chemie (International ed. in English) · 2022Article
- Direct Production of a Hyperpolarized Metabolite on a Microfluidic Chip.Analytical chemistry · 2022Article
- Quasi-continuous production of highly hyperpolarized carbon-13 contrast agents every 15 seconds within an MRI system.Communications chemistry · 2022Article
- Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques.Analytical chemistry · 2022Article
- Spatially Resolved Kinetic Model of Parahydrogen Induced Polarisation (PHIP) in a Microfluidic Chip.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Integrated impedance sensing of liquid sample plug flow enables automated high throughput NMR spectroscopy.Microsystems & nanoengineering · 2021Article
- Determination of hydrogen exchange and relaxation parameters in PHIP complexes at micromolar concentrations.Magnetic resonance (Gottingen, Germany) · 2021Article
- Automated pneumatic shuttle for magnetic field cycling and parahydrogen hyperpolarized multidimensional NMR.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Monitoring Heterogeneously Catalyzed Hydrogenation Reactions at Elevated Pressures Using In-Line Flow NMR.Analytical chemistry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex mixtures, commonly encountered in metabolomics and food analytics, are now routinely measured by nuclear magnetic resonance (NMR) spectroscopy. Since many samples must be measured, one-dimensional proton (1D 1H) spectroscopy is the experiment of choice. A common challenge in complex mixture 1H NMR spectroscopy is spectral crowding, which limits the assignment of molecular components to those molecules in relatively high abundance. This limitation is exacerbated when the sample quantity itself is limited and concentrations are reduced even further during sample preparation for routine measurement. To address these challenges, we report a novel microfluidic NMR platform integrating signal enhancement via parahydrogen induced hyperpolarisation. The platform simultaneously addresses the challenges of handling small sample quantities through microfluidics, the associated decrease in signal given the reduced sample quantity by Signal Amplification by Reversible Exchange (SABRE), and overcoming spectral crowding by taking advantage of the chemosensing aspect of the SABRE effect. SABRE at the microscale is enabled by an integrated PDMS membrane alveolus, which provides bubble-free hydrogen gas contact with the sample solution. With this platform, we demonstrate high field NMR chemosensing of microliter sample volumes, nanoliter detection volumes, and micromolar concentrations corresponding to picomole molecular sensitivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.