Evidence map›Paper›PMID 30627695›Full record

ArticleJNCI cancer spectrum2018

Epidemiology, Biology, Treatment, and Prevention of Ductal Carcinoma In Situ (DCIS).

Rinaa S Punglia, Kaitlyn Bifolck, Mehra Golshan, Constance Lehman, Laura Collins, Kornelia Polyak, Elizabeth Mittendorf, Judy Garber, Shelley E Hwang, Stuart J Schnitt and 2 more

Open access · goldAbstract read
In one paragraph

Article in JNCI cancer spectrum, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Article
  10. Article
  11. HER2-Overexpressing Ductal CarcinomaCancer prevention research (Philadelphia, Pa.) · 2020
    Article
  12. Everolimus Inhibits the Progression of Ductal CarcinomaClinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Rinaa S PungliaRadiation Oncology.
Kaitlyn BifolckMedical Oncology.
Mehra GolshanSurgical Oncology, Division of Breast Surgery, Department of Surgery.
Constance LehmanDana-Farber/Brigham and Women's Cancer Center, Boston, MA.
Laura CollinsDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA.
Kornelia PolyakMedical Oncology.
Elizabeth MittendorfSurgical Oncology, Division of Breast Surgery, Department of Surgery.
Judy GarberMedical Oncology.
Shelley E HwangDepartment of Surgery, Duke University Medical Center, Durham, NC.
Stuart J SchnittDepartment of Pathology, Brigham and Women's Hospital, Boston, MA.
Ann H PartridgeMedical Oncology.
Tari A KingSurgical Oncology, Division of Breast Surgery, Department of Surgery.
Beth Israel Deaconess Medical Center · USDana-Farber Brigham Cancer Center · USDuke Medical Center · USMassachusetts General Hospital · USRadiation Oncology Associates · USThe University of Texas MD Anderson Cancer Center · US

Funding

Targeting intratumor heterogeneity in breast cancerR35CA197623 · NCI · DANA-FARBER CANCER INST · PI KORNELIA POLYAK · 2015 to 2026
$12.4M
Myoepithelial cell differentiation defects in ductal carcinoma in situ (DCIS)U01CA143233 · NCI · DANA-FARBER CANCER INST · PI BISSELL, MINA, POLLARD, JEFFREY W. · 2009 to 2013
$2.5M
(PQC3) Genomic Diversity and Microenvironment as Drivers of Metastasis in DCISR01CA185138 · NCI · DUKE UNIVERSITY · PI HWANG, E.SHELLEY, MALEY, CARLO · 2014 to 2017
$2.0M
NCI NIH HHS R01 CA185138NCI NIH HHS R35 CA197623NCI NIH HHS U01 CA143233
6 · The paper itself

Abstract

Ductal carcinoma in situ (DCIS) is a highly heterogeneous disease. It presents in a variety of ways and may or may not progress to invasive cancer, which poses challenges for both diagnosis and treatment. On May 15, 2017, the Dana-Farber/Harvard Cancer Center hosted a retreat for over 80 breast specialists including medical oncologists, surgical oncologists, radiation oncologists, radiologists, pathologists, physician assistants, nurses, nurse practitioners, researchers, and patient advocates to discuss the state of the science, treatment challenges, and key questions relating to DCIS. Speakers and attendees were encouraged to explore opportunities for future collaboration and research to improve our understanding and clinical management of this disease. Participants were from Dana-Farber Cancer Institute, Brigham and Women's Hospital, Massachusetts General Hospital, Beth Israel Deaconess Medical Center, Duke University Medical Center, and MD Anderson Cancer Center. The discussion focused on three main themes: epidemiology, detection, and pathology; state of the science including the biology of DCIS and potential novel treatment approaches; and risk perceptions, communication, and decision-making. Here we summarize the proceedings from this event.

Identifiers

PMID30627695
PMCPMC6307658
OpenAlexW2907498602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.