ArticleComputational psychiatry (Cambridge, Mass.)2018
Visual Attention Deficits in Schizophrenia Can Arise From Inhibitory Dysfunction in Thalamus or Cortex.
Article in Computational psychiatry (Cambridge, Mass.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Apical integration theory provides a neural basis for understanding disorganization and consciousness in the schizophrenias.Current research in neurobiology · 2026Article
- Specializations in Amygdalar and Hippocampal Innervation of the Primate Nucleus Accumbens Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Review
- A neural model of modified excitation/inhibition and feedback levels in schizophrenia.bioRxiv : the preprint server for biology · 2023Article
- A neural model of modified excitation/inhibition and feedback levels in schizophrenia.Frontiers in psychiatry · 2023Article
- It's about time: Linking dynamical systems with human neuroimaging to understand the brain.Network neuroscience (Cambridge, Mass.) · 2022Article
- A causal role for the pulvinar in coordinating task-independent cortico-cortical interactions.The Journal of comparative neurology · 2021Article
- Neural Mechanisms of Visual Motion Anomalies in Autism: A Two-Decade Update and Novel Aetiology.Frontiers in neuroscience · 2021Review
- Organization of primate amygdalar-thalamic pathways for emotions.PLoS biology · 2020Article
- Hallucinations, somatic-functional disorders of PD-DLB as expressions of thalamic dysfunction.Movement disorders : official journal of the Movement Disorder Society · 2019Review
- Decreased Cross-Domain Mutual Information in Schizophrenia From Dynamic Connectivity States.Frontiers in neuroscience · 2019Article
- Biophysical Psychiatry-How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.Frontiers in psychiatry · 2019Review
- Visual Attention Deficits in Schizophrenia Can Arise From Inhibitory Dysfunction in Thalamus or Cortex.Computational psychiatry (Cambridge, Mass.) · 2018Article
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4 authors.
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Abstract
Schizophrenia is associated with diverse cognitive deficits, including disorders of attention-related oculomotor behavior. At the structural level, schizophrenia is associated with abnormal inhibitory control in the circuit linking cortex and thalamus. We developed a spiking neural network model that demonstrates how dysfunctional inhibition can degrade attentive gaze control. Our model revealed that perturbations of two functionally distinct classes of cortical inhibitory neurons, or of the inhibitory thalamic reticular nucleus, disrupted processing vital for sustained attention to a stimulus, leading to distractibility. Because perturbation at each circuit node led to comparable but qualitatively distinct disruptions in attentive tracking or fixation, our findings support the search for new eye movement metrics that may index distinct underlying neural defects. Moreover, because the cortico-thalamic circuit is a common motif across sensory, association, and motor systems, the model and extensions can be broadly applied to study normal function and the neural bases of other cognitive deficits in schizophrenia.
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