Evidence map›Paper›PMID 30627660›Full record

ArticleeNeuro

Enhancing GABAergic Transmission Improves Locomotion in a

Chia-Yen Wu, David A Gagnon, Juliette S Sardin, Urva Barot, Alex Telenson, Paulo E Arratia, Robert G Kalb

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. eNeuro
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chia-Yen WuDepartment of Pediatrics, Division of Neurology, Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
David A GagnonDepartment of Physics, Georgetown University, Washington, DC 20057.
Juliette S SardinDepartment of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104.
Urva BarotDepartment of Pediatrics, Division of Neurology, Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Alex TelensonDepartment of Pediatrics, Division of Neurology, Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Paulo E ArratiaDepartment of Physics, Georgetown University, Washington, DC 20057.
Robert G KalbDepartment of Pediatrics, Division of Neurology, Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Children's Hospital of Philadelphia · USCalifornia University of Pennsylvania · USGeorgetown University · USUniversity of Pennsylvania · US

Funding

Training Program in Neurodevelopmental DisabilitiesT32NS007413 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI AMELIA J EISCH, ERIC D MARSH · 1998 to 2026
$8.9M
Trophic Factor Signaling and Motor Neuron DeathR01NS052325 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI KALB, ROBERT G · 2006 to 2015
$3.5M
NINDS NIH HHS R01 NS052325NINDS NIH HHS T32 NS007413
6 · The paper itself

Abstract

Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by degeneration of spinal motor neurons resulting in variable degrees of muscular wasting and weakness. It is caused by a loss-of-function mutation in the survival motor neuron (

Indexed as

Adjuvants, ImmunologicAnimalsAnimals, Genetically ModifiedBiomechanical PhenomenaCaenorhabditis elegansCaenorhabditis elegans ProteinsCholinesterase InhibitorsDisease Models, AnimalForkhead Transcription FactorsGait Disorders, Neurologicgamma-Aminobutyric AcidLevamisoleLongevityMuscular Atrophy, SpinalNeuromuscular JunctionPyridostigmine BromideAdjuvants, ImmunologicCaenorhabditis elegans ProteinsCholinesterase Inhibitorsdaf-16 protein, C elegansForkhead Transcription Factorsgamma-Aminobutyric AcidLevamisolePyridostigmine Bromidesmn-1 protein, C elegansSurvival of Motor Neuron 1 ProteinagingFOXO transcription factorneuromuscular junctionSMN proteinsuppressor

Identifiers

PMID30627660
PMCPMC6325564
OpenAlexW2900594877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.