ArticleeNeuro
Ovarian Cycle Stages Modulate Alzheimer-Related Cognitive and Brain Network Alterations in Female Mice.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Adolescent intermittent ethanol exacerbates amyloid-β with age in the dorsal hippocampus of female TgF344-AD rats.Journal of Alzheimer's disease : JAD · 2026Article
- Article
- Role of the gut microbiome in mediating sex-specific differences in the pathophysiology of Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Advancing 3Rs: The Mouse Estrus Detector (MED) as a Low-Stress, Painless, and Efficient Tool for Estrus Determination in Mice.International journal of molecular sciences · 2024Article
- Plasma lipidomics in early APP/PS1 female mouse model and its relationship with brain: Is it affected by the estrous cycle?Alzheimer's research & therapy · 2024Article
- Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function.Scientific reports · 2024Article
- Morphine pharmacokinetics and opioid transporter expression at the blood-retina barrier of male and female mice.Frontiers in pharmacology · 2023Article
- Evaluating the interplay between estrous cyclicity and flurothyl-induced seizure susceptibility inmicroPublication biology · 2023Article
- Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity.Biological psychiatry · 2021Article
- Optogenetic manipulation of the prelimbic cortex during fear memory reconsolidation alters fear extinction in a preclinical model of comorbid PTSD/AUD.Psychopharmacology · 2021Article
- MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.Scientific reports · 2021Article
- Disease progression modelling from preclinical Alzheimer's disease (AD) to AD dementia.Scientific reports · 2021Article
- Chronic BACE-1 Inhibitor Administration in TASTPM Mice (APP KM670/671NL and PSEN1 M146V Mutation): An EEG Study.International journal of molecular sciences · 2020Article
- Reproductive status impact on tau phosphorylation induced by chronic stress.Neurobiology of stress · 2020Article
- Sex-dependent effect ofDisease models & mechanisms · 2020Review
- A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.Science translational medicine · 2020Article
- Research Progress on Alzheimer's Disease and Resveratrol.Neurochemical research · 2020Review
- VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice.Molecular neurodegeneration · 2020Article
- Estrous Cycle Monitoring in Mice with Rapid Data Visualization and Analysis.Bio-protocol · 2019Article
- Exercise prevents obesity-induced cognitive decline and white matter damage in mice.Neurobiology of aging · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Alzheimer's disease (AD) begins several decades before the onset of clinical symptoms, at a time when women may still undergo reproductive cycling. Whether ovarian functions alter substrates of AD pathogenesis is unknown. Here we show that ovarian cycle stages significantly modulate AD-related alterations in neural network patterns, cognitive impairments, and pathogenic protein production in the hAPP-J20 mouse model of AD. Female hAPP mice spent more time in estrogen-dominant cycle stages and these ovarian stages worsened AD-related network dysfunction and cognitive impairments. In contrast, progesterone-dominant stages and gonadectomy attenuated these AD-related deficits. Further studies revealed a direct role for estradiol in stimulating neural network excitability and susceptibility to seizures in hAPP mice and increasing amyloid beta levels. Understanding dynamic effects of the ovarian cycle on the female nervous system in disease, including AD, is of critical importance and may differ from effects on a healthy brain. The pattern of ovarian cycle effects on disease-related networks, cognition, and pathogenic protein expression may be relevant to young women at risk for AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.