Evidence map›Paper›PMID 30627640›Full record

ArticleeNeuro

Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus.

S D James, V E Hawkins, B Falquetto, D N Ruskin, S A Masino, T S Moreira, M L Olsen, D K Mulkey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

S D JamesDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT.
V E HawkinsDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT.
B FalquettoDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT.
D N RuskinNeuroscience Program, Department of Psychology, Trinity College Hartford, CT.
S A MasinoNeuroscience Program, Department of Psychology, Trinity College Hartford, CT.
T S MoreiraDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
M L OlsenSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA.ORCID 0000-0003-1394-664X
D K MulkeyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT.ORCID 0000-0002-7040-3927
University of Connecticut · USHartford Financial Services (United States)Universidade de São Paulo · BRVirginia Tech · US

Funding

Glial chemosensitivity: pH sensing and interactions with neuronal chemoreceptorsR01HL104101 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, OLSEN, MICHELLE L · 2010 to 2024
$5.5M
The Role of Adenosine in Ketogenic Diet TherapyR01NS065957 · NINDS · TRINITY COLLEGE · PI BOISON, DETLEV, GEIGER, JONATHAN DAVID · 2010 to 2021
$3.9M
Metabolic therapy to relieve pain: ketogenic diet and adenosineR15AT008742 · NCCIH · TRINITY COLLEGE · PI David Nathaniel Ruskin · 2015 to 2026
$1.8M
Ketogentic diet-induced changes in the cerebrospinal fluid: biomarkers and mechanismsR15NS066392 · NINDS · TRINITY COLLEGE · PI MASINO, SUSAN A · 2010 to 2015
$583k
Defining Astrocyte Heterogenity Across the Brainstem Respiratory CircuitR21NS099887 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K · 2019 to 2020
$443k
NCCIH NIH HHS R15 AT008742NHLBI NIH HHS R01 HL104101NINDS NIH HHS R01 NS065957NINDS NIH HHS R15 NS066392NINDS NIH HHS R21 NS099887
6 · The paper itself

Abstract

A subset of neurons in the retrotrapezoid nucleus (RTN) function as respiratory chemoreceptors by regulating depth and frequency of breathing in response to changes in tissue CO

Indexed as

6-Cyano-7-nitroquinoxaline-2,3-dioneAdenosineAnimalsAnimals, NewbornBariumCarbon DioxideChemoreceptor CellsExcitatory Amino Acid AntagonistsFemaleMaleMice, Inbred C57BLMice, TransgenicNeuronal PlasticityNeurotransmitter AgentsPotassium Channel BlockersPurinergic Agents6-Cyano-7-nitroquinoxaline-2,3-dioneAdenosineBariumCarbon DioxideExcitatory Amino Acid AntagonistsNeurotransmitter AgentsPotassium Channel BlockersPurinergic AgentsReceptors, Purinergic P1Sodium Channel BlockersTetrodotoxinbrain slicecellularchemoreceptionnetworkRTN

Identifiers

PMID30627640
PMCPMC6325544
OpenAlexW2902640240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.