ArticleNeurobiology of stress2019
Shared gray matter reductions across alcohol use disorder and posttraumatic stress disorder in the anterior cingulate cortex: A dual meta-analysis.
Article in Neurobiology of stress, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 6 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed, 6 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Pooled it
- Extended functional connectivity of convergent structural alterations among individuals with PTSD: a neuroimaging meta-analysis.Behavioral and brain functions : BBF · 2022Pooled it
- How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings.Human brain mapping · 2022Pooled it
- Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis.Psychopharmacology · 2021Pooled it
- Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder.Scientific reports · 2021Pooled it
- Stress and the brain: Emotional support mediates the association between myelination in the right supramarginal gyrus and perceived chronic stress.Neurobiology of stress · 2023Article
- Resting-state connectivity subtype of comorbid PTSD and alcohol use disorder moderates improvement from integrated prolonged exposure therapy in Veterans.Psychological medicine · 2023Article
- Common Gray Matter Reductions in Alcohol Use and Obsessive-Compulsive Disorders: A Meta-analysis.Biological psychiatry global open science · 2022Article
- Baseline brain and behavioral factors distinguish adolescent substance initiators and non-initiators at follow-up.Frontiers in psychiatry · 2022Article
- Article
- Higher-Order Language Dysfunctions in Individuals with Alcohol Use Disorder.Journal of clinical medicine · 2021Article
- Posttraumatic Stress Symptoms Predict Transition to Future Adolescent and Young Adult Moderate to Heavy Drinking in the NCANDA Sample.Current addiction reports · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
The considerable comorbidity of posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) poses a greater public health burden than either condition alone. Although there is a substantial body of evidence linking the direct neurotoxic effect of heavy drinking to gray matter (GM) deficits, as well as a growing body of literature supporting a strong association between PTSD and GM alterations, there is scant research interrogating the direct interaction of the two disorders. In order to generate data-driven, specific hypotheses regarding the overlapping neural substrates of PTSD and AUD, we conducted a meta-analysis of GM volumes in each disorder relative to healthy control subjects. We found shared GM deficits in the anterior cingulate cortex (ACC) across both disorders relative to healthy control participants. These findings suggest that reduced volumes of the ACC across PTSD and AUD may have implications for the development, expression, or treatment of symptoms linked to these frequently co-existing disorders. Recommendations are made for future work aimed at delineating the specific and shared effects of traumatic stress and alcoholism on neural integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.