Evidence map›Paper›PMID 30627586›Full record

ArticleBioMed research international2018

Neuroprotection by Paeoniflorin against Nuclear Factor Kappa B-Induced Neuroinflammation on Spinal Cord Injury.

Bin Wang, Wangying Dai, Lijun Shi, Honglin Teng, Xigong Li, Jing Wang, Wujun Geng

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Bin WangDepartment of Orthopedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, China.
Wangying DaiDepartment of Spine Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Lijun ShiDepartment of Pharmacology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Honglin TengDepartment of Spine Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Xigong LiDepartment of Orthopedic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Jing WangDepartment of Spine Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.ORCID 0000-0002-7959-0685
Wujun GengDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.ORCID 0000-0001-5599-3036
Wenzhou Medical University · CNZhejiang Chinese Medical University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute spinal cord injury (SCI) is one of the most common and devastating causes of sensory or motor dysfunction. Nuclear factor-kappa B(NF-

methodImmunohistochemical analysis, western blot, real-time quantitative PCR, immunofluorescence staining, and histopathological and behavioral evaluation were used to explore the effects of paeoniflorin after SCI for 14 days.

resultsIn this study, PF treatment significantly inhibited NF-

conclusionThese results suggest that the neuroprotective effects of PF are related to the inhibition of the NF-

Indexed as

Spinal Cord InjuriesAcute DiseaseAnimalsFemaleInflammationMaleNerve Tissue ProteinsNeuroprotective AgentsNF-kappa BPaeoniaPlant ExtractsPlant RootsRatsRats, Sprague-DawleyNerve Tissue ProteinsNeuroprotective AgentsNF-kappa BPlant Extracts

Identifiers

PMID30627586
PMCPMC6304651
OpenAlexW2903021063

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.