Evidence map›Paper›PMID 30627560›Full record

ReviewBioMed research international2018

A Brief Review on the Neuroprotective Mechanisms of Vitexin.

Layana Karine F Lima, Suyanne Kássia S Pereira, Ronaldo Dos Santos S Junior, Felipe Pereira da S Santos, Alyandra de Sousa Nascimento, Chistiane Mendes Feitosa, Juliana de Sousa Figuerêdo, Antonio do Nascimento Cavalcante, Edigênia Cavalcante da C Araújo, Mahendra Rai

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Phytochemicals with potential NMDAR-inhibitory activities: a review of neuroprotective mechanisms against excitotoxicity.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Antimicrobial photodynamic therapy with Brazilian green propolis controls intradermal infection induced by methicillin-resistant Staphylococcus aureus and modulates the inflammatory response in a murine model.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Article
  13. Review
  14. Beneficial Role of Vitexin in Parkinson's Disease.The Malaysian journal of medical sciences : MJMS · 2023
    Review
  15. Review
  16. Review
  17. Enzymatic Synthesis of Novel Vitexin Glucosides.Molecules (Basel, Switzerland) · 2021
    Article
  18. Review
  19. Review
  20. Protective effects of organic extracts ofNeural regeneration research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Layana Karine F LimaPost-Graduate Programs in Pharmaceutical Sciences, Federal University of Piaui, Ininga, 64.049-550, Teresina, Piauí, Brazil.ORCID 0000-0002-1431-2422
Suyanne Kássia S PereiraPost-Graduate Programs in Pharmaceutical Sciences, Federal University of Piaui, Ininga, 64.049-550, Teresina, Piauí, Brazil.ORCID 0000-0002-0609-5130
Ronaldo Dos Santos S JuniorPost-Graduate Programs in Chemistry, Federal University of Piaui, Ininga, 64.049-550, Teresina, Piauí, Brazil.ORCID 0000-0001-7219-0614
Felipe Pereira da S SantosPost-Graduate Programs in Chemistry, Federal University of Piaui, Ininga, 64.049-550, Teresina, Piauí, Brazil.
Alyandra de Sousa NascimentoPost-Graduate Programs in Chemistry, Federal University of Piaui, Ininga, 64.049-550, Teresina, Piauí, Brazil.
Chistiane Mendes FeitosaPost-Graduate Programs in Chemistry, Federal University of Piaui, Ininga, 64.049-550, Teresina, Piauí, Brazil.
Juliana de Sousa FiguerêdoPost-Graduate Programs in Chemistry, Federal University of Piaui, Ininga, 64.049-550, Teresina, Piauí, Brazil.
Antonio do Nascimento CavalcantePost-Graduate Programs in Chemistry, Federal University of Piaui, Ininga, 64.049-550, Teresina, Piauí, Brazil.ORCID 0000-0002-8179-0598
Edigênia Cavalcante da C AraújoUnivasf, Collegiate of Pharmaceutical Sciences, Avenue José de Sá Maniçoba, s/no, Center, CEP 56304-205 Petrolina, PE, Brazil.
Mahendra RaiDepartment of Biotechnology SGB Amravati University, Amravati PIN-444602, Maharashtra, India.ORCID 0000-0001-7645-9801
Universidade Federal do Piauí · BRSant Gadge Baba Amravati University · INUniversidade do Vale do Sapucaí · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neural dysfunction is triggered by cellular and molecular events that provoke neurotoxicity and neural death. Currently, neurodegenerative diseases are increasingly common, and available treatments are focused on relieving symptoms. Based on the above, in this review we describe the participation of vitexin in the main events involved in the neurotoxicity and cell death process, as well as the use of vitexin as a therapeutic approach to suppress or attenuate neurodegenerative progress. Vitexin contributes to increasing neuroprotective factors and pathways and counteract the targets that induce neurodegeneration, such as redox imbalance, neuroinflammation, abnormal protein aggregation, and reduction of cognitive and/or motor impairment. The results obtained provide substantial evidence to support the scientific exploration of vitexin in these pathologies, since their effects are still little explored for this direction.

Indexed as

AnimalsApigeninCell DeathHumansInflammationNeurodegenerative DiseasesNeuroprotective AgentsProtein Aggregation, PathologicalApigeninNeuroprotective Agentsvitexin

Identifiers

PMID30627560
PMCPMC6304565
OpenAlexW2903042997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.