ArticleThe mental health clinician2019
Antipsychotic use and fracture risk: An evaluation of incidence at a Veterans Affairs medical center.
Article in The mental health clinician, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Antipsychotic medication use and fracture: a case-control study.Scientific reports · 2023Article
- Hyperprolactinemia and bone.Pituitary · 2020Review
- Drug-induced osteoporosis/osteomalacia: analysis in the French and Spanish pharmacovigilance databases.European journal of clinical pharmacology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecent meta-analyses have found a correlation between schizophrenia and increased fracture risk with one contributing factor potentially being antipsychotic-induced hyperprolactinemia, which may accelerate bone turnover. The objective of this study is to evaluate fracture rates in patients on long-term antipsychotic therapy to see if screening for osteoporosis should be included with routine monitoring.
methodsPatients exposed to antipsychotics for ≥3 months during a 10-year study period were included in this retrospective analysis. The primary outcome was to compare fracture rates in those exposed to long-term antipsychotics to a control group with similar demographics and comorbidities not receiving antipsychotics. Secondary outcomes included examining the risk of fracture by medication use and comorbid disease states associated with causing osteoporosis, vitamin D level monitoring and fracture presence, and the time to first fracture.
resultsLong-term use of antipsychotics was not associated with an increased rate of fractures compared to the control group in this study. End-stage renal disease, tobacco use, alcohol use, glucocorticoids, antiepileptics, and proton pump inhibitors were associated with higher risk of fracture ( DISCUSSION: Long-term antipsychotic use is not associated with an increased risk of fractures. Further long-term prospective studies are necessary to further investigate this correlation. Screening for osteoporosis should follow guideline-driven recommendations for at-risk populations.
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