ArticleTranslational vision science & technology2019
Gray Matter Volume Changes in Patients With Acute Eye Pain: A Voxel-Based Morphometry Study.
Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 19 citations in OpenAlex.
- Detection of abnormal cortex in patients with orbital fractures.Scientific reports · 2025Article
- Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry.International journal of ophthalmology · 2025Article
- Altered static and dynamic spontaneous brain activity in patients with dysthyroid optic neuropathy: a resting-state fMRI study.Frontiers in neuroscience · 2024Article
- Altered dynamic brain activity and functional connectivity in thyroid-associated ophthalmopathy.Human brain mapping · 2023Article
- Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study.Scientific reports · 2022Article
- Regional brain atrophy in patients with chronic ankle instability: A voxel-based morphometry study.Frontiers in neuroscience · 2022Article
- Altered Spontaneous Brain Activity Patterns of Meibomian Gland Dysfunction in Severely Obese Population Measured Using the Fractional Amplitude of Low-Frequency Fluctuations.Frontiers in psychiatry · 2022Article
- Brain Activity in Different Brain Areas of Patients With Dry Eye During the Female Climacteric Period According to Voxel-Based Morphometry.Frontiers in neurology · 2022Article
- The Predictive Potential of Altered Voxel-Based Morphometry in Severely Obese Patients With Meibomian Gland Dysfunction.Frontiers in neuroscience · 2022Article
- Article
- Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy.Investigative ophthalmology & visual science · 2021Article
- Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study.International journal of ophthalmology · 2021Article
- Morphological and microstructural brain changes in thyroid-associated ophthalmopathy: a combined voxel-based morphometry and diffusion tensor imaging study.Journal of endocrinological investigation · 2020Article
- Cerebrospinal fluid T1 value phantom reproduction at scan room temperature.Journal of applied clinical medical physics · 2019Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe present study was attempted to compare the differences in gray matter volume (GMV) between the acute eye pain (EP) patients and the healthy controls (HCs) using voxel-based morphometry (VBM), and to explore the relationship with clinical features and behavioral performance.
methodsA total of 24 patients (17 males, 7 females) with acute EP and 24 (17 males, 7 females) age-, sex-, and education-matched HCs were recruited from the Ophthalmology Department of the First Affiliated Hospital of Nanchang University. Functional magnetic resonance imaging (fMRI) scans were conducted in all subjects. We analyzed the original three-dimensional (3D) T1 brain images by VBM and compared the GMV values with the HCs. The acute EP patients can be distinguished from the HCs by receiver operating characteristic (ROC) curve.
resultsCompared with HCs, the acute EP patients had significantly lower GMV values in the brain regions of the left cerebellum posterior lobe, the left limbic lobe, the right insula, the left insula, the left thalamus, the left caudate, and the right cuneus. In addition, the WMV values of the whole brain in acute EP patients decreased slightly.
conclusionsThese results demonstrated that the acute EP patients showed an abnormal reduction in GMV in some brain regions, which might provide valuable information for further exploration of underlying neural mechanisms. These abnormal brain regions may reflect the functional disorders of acute EP patients in somatosensory, motor, cognitive functions, and so on. TRANSLATIONAL RELEVANCE: The VBM study provides a diagnostic method for identifying the cause of acute EP, additionally, a novel direction was presented for further exploration of underlying neural mechanisms of acute EP.
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