Evidence map›Paper›PMID 30627395›Full record

ArticleChemical science2018

Direct introduction of nitrogen and oxygen functionality with spatial control using copper catalysis.

James B Shaum, David J Fisher, Miranda M Sroda, Luis Limon, Javier Read de Alaniz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James B ShaumDepartment of Chemistry and Biochemistry , University of California , Santa Barbara , California 93106 , USA . Email: javier@chem.ucsb.edu.ORCID 0000-0003-1664-1091
David J FisherDepartment of Chemistry and Biochemistry , University of California , Santa Barbara , California 93106 , USA . Email: javier@chem.ucsb.edu.
Miranda M SrodaDepartment of Chemistry and Biochemistry , University of California , Santa Barbara , California 93106 , USA . Email: javier@chem.ucsb.edu.ORCID 0000-0002-5939-7722
Luis LimonDepartment of Chemistry and Biochemistry , University of California , Santa Barbara , California 93106 , USA . Email: javier@chem.ucsb.edu.
Javier Read de AlanizDepartment of Chemistry and Biochemistry , University of California , Santa Barbara , California 93106 , USA . Email: javier@chem.ucsb.edu.ORCID 0000-0003-2770-9477

Funding

Upgrade of 500 MHz NMR SpectrometerS10OD012077 · OD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ZHANG, LIMING · 2013 to 2013
$347k
NIH HHS S10 OD012077
6 · The paper itself

Abstract

Synthetic chemists have spent considerable effort optimizing the synthesis of nitrogen and oxygen containing compounds through a number of methods; however, direct introduction of N- and O-functionality remains challenging. Presented herein is a general method to allow for the simultaneous installation of N- and O-functionality to construct unexplored N-O heterocyclic and amino-alcohol scaffolds. This transformation uses earth abundant copper salts to facilitate the formation of a carbon-centered radical and subsequent carbon-nitrogen bond formation. The intermediate aminoxyl radical is terminated by an intramolecularly appended carbon-centered radical. We have exploited this methodology to also access amino-alcohols with a range of aliphatic and aromatic linkers.

Identifiers

PMID30627395
PMCPMC6289103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.