Associated Factors of Maintenance in Patients under Treatment with Methadone: A Comprehensive Systematic Review and Meta-Analysis.

Farzaneh Farmani, Hadi Farhadi, Younes Mohammadi

Abstract readReview

In one paragraph

Review in Addiction & health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

Effectiveness of the WeChat-based mini-program ("Sober Time ACT") on individuals with hazardous drinking in China: a randomized controlled trial.BMC medicine · 2025
Trial
Comparative effectiveness of alternative initial doses of opioid agonist treatment for individuals with opioid use disorder: a protocol for a retrospective population-based study using target trial emulation in British Columbia, Canada.BMJ open · 2025
Article
A review of factors associated with methadone maintenance treatment adherence and retention in Vietnam.Drug and alcohol dependence · 2023
Review
Comparison of Psychopathologic Characteristics between Individuals Undergoing Methadone Maintenance Treatment, Opioid Dependents, and Control Group.Addiction & health · 2022
Article
Frontal Lobe Functions, Demoralization, Depression and Craving as Prognostic Factors and Positive Outcomes of Patients with Heroin Use Disorder Receiving 6 Months of Methadone Maintenance Treatment.International journal of environmental research and public health · 2022
Article
Comparative effectiveness of buprenorphine-naloxone versus methadone for treatment of opioid use disorder: a population-based observational study protocol in British Columbia, Canada.BMJ open · 2020
Article
Prescribing Buprenorphine for Opioid Use Disorders in the ED: A Review of Best Practices, Barriers, and Future Directions.Open access emergency medicine : OAEM · 2020
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Farzaneh FarmaniMSc Student, Department of Psychology, School of Educational Sciences and Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

Hadi FarhadiAssistant Professor, Department of Psychology, School of Educational Sciences and Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

Younes MohammadiAssistant Professor, Modeling of Noncommunicable Diseases Research Center AND Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis comprehensive systematic review and meta-analysis were performed to assess the associated factors of maintenance in patients with methadone therapy in the world.

methodsA systematic literature review was performed from several scientific databases; these include PubMed, Scopus, ISI Web of Science, and MEDLINE. We searched the following keywords: "Methadone", "Maintenance", "Retention", "Meta-analysis" and "Associated factors". Data were selected based on the inclusion and exclusion criteria. The purpose of this study was to assess the associated factors of maintenance in patients under treatment with methadone by an overall effect size, odds ratio (OR) [95% confidence interval (CI)] using meta-analysis.

findingsWe selected 24 researches out of 94413 for our study based on the inclusion and exclusion criteria for systematic review and meta-analysis. The pooled recognized five significant positive associations of age, marital status, employment status, gender, and length of treatment with methadone usage (OR age = 3.566, 95% CI = 3.296-3.836, P < 0.001; OR marital status = 1.101, 95% CI = 1.028-1.175, P = 0.025; OR employment = 1.157, 95% CI = 1.060-1.254, P = 0.015; OR gender = 4.686, 95% CI = 4.434-4.939, P < 0.001; OR duration of treatment = 1.543, 95% CI = 1.443-1.647, P < 0.001; respectively). However, education and injection status showed a non-significant positive association with methadone usage (OR education level = 1.279, 95% CI = 0.976-1.583, P = 0.266; OR injection status = 1.205, 95% CI = 0.725-1.658, P = 0.442).

conclusionThis systematic-review and meta-analysis study displayed that factors such as age, marital and employment status, gender, and duration of treatment are effective on maintenance in patients under treatment of methadone.

Indexed as

Associated factorsMaintenanceMeta-analysisMethadone

Identifiers

PMID30627384

DOI10.22122/ahj.v10i1.488

PMCPMC6312561

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.