ArticleIranian journal of basic medical sciences2018
Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats.
Article in Iranian journal of basic medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Ethanolic Extract of Pomegranate (Animals : an open access journal from MDPI · 2025Article
- Pomegranate: A review of the heavenly healer's past, present, and future.Iranian journal of basic medical sciences · 2023Review
- Punica granatum seed oil detracts peritoneal adhesion: Perusing antioxidant, anti-inflammatory, antifibrotic, and antiangiogenic impacts.Physiological reports · 2022Article
- A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological study.Molecular biology reports · 2022Article
- Potential protective effect of astaxanthin on ovary ischemia-reperfusion injury.Iranian journal of basic medical sciences · 2022Article
- Effects of pomegranate seed oil on lower-extremity ischemia-reperfusion damage: Insights into oxidative stress, inflammation, and cell death.Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats. MATERIALS AND
methodsFifty-six female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Operation, Group 2; Ischemia, Group 3; Ischemia + Reperfusion, Group 4; Ischemia + Pomegranate 0,32 ml / kg (IP), Group 5; Ischemia + Pomegranate 0.64 ml / kg, Group 6; Ischemia + Pomegranate 0,32 ml / kg + reperfusion, Group 7; Ischemia + Pomegranate 0,64 ml / kg + reperfusion. Three hours after ischemia and 3 hours after reperfusion, the study was terminated.
resultsWhile NADPH oxidase activity, MDA and TNF-α levels were significantly increased, SOD activity and GSH levels were reduced in ischemia and I/R groups. Low dose pomegranate seed oil application reduced significantly oxidative stress and NADPH oxidase activity in both ischemic and ischemic/reperfusion groups. At the same time, low-dose pomegranate seed oil extract reduced TNF-α levels and significantly increased antioxidant activity.
conclusionPSO demonstrated an important therapeutic effect in the treatment of ovarian ischemia and reperfusion injury.
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Registered trials
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