ArticleMalawi medical journal : the journal of Medical Association of Malawi2018
Effect of mazEF, higBA and relBE toxin-antitoxin systems on antibiotic resistance in Pseudomonas aeruginosa and Staphylococcus isolates.
Article in Malawi medical journal : the journal of Medical Association of Malawi, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- Exploring antibiotic-induced persister formation and bacterial persistence genes in clinical isolates from Burkina Faso.BMC infectious diseases · 2024Article
- Evaluating the antibacterial effect of meropenem-loaded chitosan/sodium tripolyphosphate (TPP) nanoparticles on Acinetobacter baumannii isolated from hospitalized patients.BMC infectious diseases · 2024Article
- Distribution of lineages and type II toxin-antitoxin systems among rifampin-resistant Mycobacterium Tuberculosis Isolates.PloS one · 2024Article
- Effect of ZnO nanoparticles on biofilm formation and gene expression of the toxin-antitoxin system in clinical isolates of Pseudomonas aeruginosa.Annals of clinical microbiology and antimicrobials · 2023Article
- Type II Toxin-Antitoxin Systems inToxins · 2023Review
- Evaluation of toxin-antitoxin genes, antibiotic resistance, and virulence genes in Pseudomonas aeruginosa isolates.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Genome sequence ofHeliyon · 2022Article
- Pseudomonas aeruginosa persister cell formation upon antibiotic exposure in planktonic and biofilm state.Scientific reports · 2022Article
- PrrT/A, a Pseudomonas aeruginosa Bacterial Encoded Toxin-Antitoxin System Involved in Prophage Regulation and Biofilm Formation.Microbiology spectrum · 2022Article
- Antitoxin CrlA of CrlTA Toxin-Antitoxin System in a Clinical IsolateFrontiers in microbiology · 2022Article
- Correlation betweenMicroorganisms · 2021Article
- Identification of a Toxin-Antitoxin System That Contributes to Persister Formation by Reducing NAD inMicroorganisms · 2021Article
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
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Abstract
Background: A toxin-antitoxin (TA) system is a set of two or more closely linked genes that are encoded as a poison and a corresponding antidote on a protein. In typical bacterial physiology, an antitoxin binds to a toxin and neutralizes it, which prevents the bacterium from killing itself. We aimed to determine whether Methods: This study included 92 Results: RelBE and higBA genes were detected in 100% of Conclusion: Studies on the prevalence and functionality of TA systems emphasize that it may be possible to have new sensitive regions in bacteria by activating TA systems. The results of this study lead to the idea that resistance to antibiotics can be reduced by increasing TA gene expression levels. But there is need for further studies to support and develop this issue.
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