ArticleJournal of clinical medicine research2019
Alcohol Withdrawal: Possible Risk of Latent Scurvy Appearing as Tiredness: A STROBE-Compliant Study.
Article in Journal of clinical medicine research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study.Antioxidants (Basel, Switzerland) · 2021Article
- Scurvy: A Rare Cause of Anemia.Cureus · 2019Article
- Adding an orange to the banana bag: vitamin C deficiency is common in alcohol use disorders.Critical care (London, England) · 2019Observational
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the prevalence of vitamin C deficiency in the population of individuals who are withdrawing from alcohol, and about possible consequences of latent scurvy. The aim of this study was to evaluate the prevalence of vitamin C deficiency in patients who were withdrawing from alcohol, its correlation with latent scurvy (mainly tiredness and weakness) and the change in the latter symptoms at 3 months after oral vitamin C supplementation.
methodsA total of 47 patients (33 males, 14 females) who volunteered to undertake alcohol detoxification were included prospectively between January 2014 and November 2016. Determination of vitamin C blood levels was performed, and selected clinical signs of latent scurvy were recorded in a structured questionnaire. The decrease of tiredness after vitamin C supplementation was also studied 3 months after the inclusion of patients who had no other explanation for their weakness.
resultsAbout 57.44% of the patients were affected by vitamin C deficiency (< 11.4 mol/L). Less than one-third (29.70%) had a normal plasma vitamin C level. There was a clear correlation between decreased vitamin C levels and the presence of tiredness (P = 0.003) and no correlation between gum inflammation or purpura (P = 0.97 and 0.44 respectively). After 3 months of alcohol withdrawal and vitamin C supplementation, 89% of the patients reported a decrease of tiredness.
conclusionsVitamin C deficiency is prevalent in patients undertaking alcohol detoxification. Patients with this vitamin deficiency status often suffer from tiredness, which may be symptoms of latent scurvy. Even if tiredness is a highly nonspecific symptom, presence of fatigue should draw attention and the vitamin C level should be determined. Our preliminary data suggest that vitamin C supplementation, may decrease fatigue and improve patient's quality of life. This last evolution needs to be confirmed by a double-blind randomized study.
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