Evidence map›Paper›PMID 30627150›Full record

ArticleNeural plasticity2018

Methods to Compare Predicted and Observed Phosphene Experience in tACS Subjects.

Aprinda Indahlastari, Aditya K Kasinadhuni, Christopher Saar, Kevin Castellano, Bakir Mousa, Munish Chauhan, Thomas H Mareci, Rosalind J Sadleir

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural plasticity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aprinda IndahlastariSchool of Biological and Health Systems Engineering, Arizona State University, USA.ORCID 0000-0002-5994-5514
Aditya K KasinadhuniDepartment of Biomedical Engineering, University of Florida, USA.ORCID 0000-0002-9889-0667
Christopher SaarSchool of Biological and Health Systems Engineering, Arizona State University, USA.
Kevin CastellanoDepartment of Biomedical Engineering, University of Florida, USA.ORCID 0000-0002-6908-6389
Bakir MousaSchool of Biological and Health Systems Engineering, Arizona State University, USA.ORCID 0000-0002-3351-0387
Munish ChauhanSchool of Biological and Health Systems Engineering, Arizona State University, USA.ORCID 0000-0003-2415-2407
Thomas H MareciDepartment of Biochemistry and Molecular Biology, University of Florida, USA.
Rosalind J SadleirSchool of Biological and Health Systems Engineering, Arizona State University, USA.ORCID 0000-0001-9789-2129

Funding

Mechanism and dosimetry exploration in transcranial electrical stimulation using magnetic resonance current mapping methods.RF1MH114290 · NIMH · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI SADLEIR, ROSALIND J · 2017 to 2017
$2.0M
In vivo imaging of therapeutic electric current flowR21NS081646 · NINDS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI SADLEIR, ROSALIND J · 2014 to 2015
$410k
NIH HHS R21NS081646NIMH NIH HHS RF1 MH114290
6 · The paper itself

Abstract

Background: Phosphene generation is an objective physical measure of potential transcranial alternating current stimulation (tACS) biological side effects. Interpretations from phosphene analysis can serve as a first step in understanding underlying mechanisms of tACS in healthy human subjects and assist validation of computational models. Objective/Hypothesis: This preliminary study introduces and tests methods to analyze predicted phosphene occurrence using computational head models constructed from tACS recipients against verbal testimonies of phosphene sensations. Predicted current densities in the eyes and the occipital lobe were also verified against previously published threshold values for phosphenes. Methods: Six healthy subjects underwent 10 Hz tACS while being imaged in an MRI scanner. Two different electrode montages, T7-T8 and Fpz-Oz, were used. Subject ratings of phosphene experience were collected during tACS and compared against current density distributions predicted in eye and occipital lobe regions of interest (ROIs) determined for each subject. Calculated median current densities in each ROI were compared to minimum thresholds for phosphene generation. Main Results: All subjects reported phosphenes, and predicted median current densities in ROIs exceeded minimum thresholds for phosphenes found in the literature. Higher current densities in the eyes were consistently associated with decreased phosphene generation for the Fpz-Oz montage. There was an overall positive association between phosphene perceptions and current densities in the occipital lobe. Conclusions: These methods may have promise for predicting phosphene generation using data collected during in-scanner tACS sessions and may enable better understanding of phosphene origin. Additional empirical data in a larger cohort is required to fully test the robustness of the proposed methods. Future studies should include additional montages that could dissociate retinal and occipital stimulation.

Indexed as

Transcranial Direct Current StimulationAdultHumansMagnetic Resonance ImagingPhosphenesVisual CortexYoung Adult

Identifiers

PMID30627150
PMCPMC6304915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.