Evidence map›Paper›PMID 30627085›Full record

ReviewFrontiers in cellular neuroscience2018

Synaptopathology Involved in Autism Spectrum Disorder.

Shiqi Guang, Nan Pang, Xiaolu Deng, Lifen Yang, Fang He, Liwen Wu, Chen Chen, Fei Yin, Jing Peng

Abstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.Frontiers in cellular and infection microbiology · 2022
    Pooled it
  3. Pooled it
  4. Article
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  6. Expression of the Human R163C-International journal of molecular sciences · 2026
    Article
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  19. Review
  20. Integrated genetic analysis reveals synaptic mFrontiers in molecular neuroscience · 2026
    Article

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shiqi GuangDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Nan PangDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Xiaolu DengDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Lifen YangDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Fang HeDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Liwen WuDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Chen ChenDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Fei YinDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Jing PengDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental disorders characterized by impaired social communication, social interaction and repetitive behaviors. ASD affects 1 in 59 children, and is about 4 times more common among boys than among girls. Strong genetic components, together with environmental factors in the early stage of development, contribute to the pathogenesis of ASD. Multiple studies have revealed that mutations in genes like

Indexed as

ASDautismsynapsesynapse eliminationsynaptic plasticitysynaptic transmissionsynaptogenesis

Identifiers

PMID30627085
PMCPMC6309163

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.