Evidence map›Paper›PMID 30627029›Full record

ReviewKorean journal of radiology2019

Gadolinium Deposition in the Brain: Current Updates.

Jin Woo Choi, Won-Jin Moon

Abstract readReview
In one paragraph

Review in Korean journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jin Woo ChoiDepartment of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.ORCID 0000-0002-0716-5137
Won-Jin MoonDepartment of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.ORCID 0000-0002-8925-7376

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gadolinium-based contrast agents (GBCAs) are commonly used for enhancement in MR imaging and have long been considered safe when administered at recommended doses. However, since the report that nephrogenic systemic fibrosis is linked to the use of GBCAs in subjects with severe renal diseases, accumulating evidence has suggested that GBCAs are not cleared entirely from our bodies; some GBCAs are deposited in our tissues, including the brain. GBCA deposition in the brain is mostly linked to the specific chelate structure of the GBCA: linear GBCAs were responsible for brain deposition in almost all reported studies. This review aimed to summarize the current knowledge about GBCA brain deposition and discuss its clinical implications.

Indexed as

BrainContrast MediaGadoliniumGadolinium DTPAHumansMagnetic Resonance ImagingContrast MediaGadoliniumGadolinium DTPABrain depositionChelating ligandDeposition mechanismGadoilniumMinistry of Food and Drug Safety in KoreaPharmacovigilance and Risk Assessment CommitteeThermodynamic stability

Identifiers

PMID30627029
PMCPMC6315073

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.