Evidence map›Paper›PMID 30626974›Full record

ArticleNature2019

Calicivirus VP2 forms a portal-like assembly following receptor engagement.

Michaela J Conley, Marion McElwee, Liyana Azmi, Mads Gabrielsen, Olwyn Byron, Ian G Goodfellow, David Bhella

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 156 citations in OpenAlex.

  1. Article
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  3. Plscr1 inhibits murine norovirus entry.bioRxiv : the preprint server for biology · 2026
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  10. Review
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  19. Functional diversity in GII.4 norovirus entry: HBGA binding and capsid clustering dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Michaela J ConleyMedical Research Council University of Glasgow Centre for Virus Research, Glasgow, UK.
Marion McElweeMedical Research Council University of Glasgow Centre for Virus Research, Glasgow, UK.
Liyana AzmiInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Mads GabrielsenCRUK Beatson Institute, Glasgow, UK.
Olwyn ByronSchool of Life Sciences, University of Glasgow, Glasgow, UK.
Ian G GoodfellowDivision of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.
David BhellaMedical Research Council University of Glasgow Centre for Virus Research, Glasgow, UK. david.bhella@glasgow.ac.uk.
Medical Research Council · GBUniversity of Glasgow · GBCancer Research UK Scotland Institute · GBMRC University of Glasgow Centre for Virus Research · GBUniversity of Cambridge · GB

Funding

Medical Research Council G0801822Medical Research Council MC_UU_12014/7Wellcome Trust 207498/Z/17/Z
6 · The paper itself

Abstract

To initiate infection, many viruses enter their host cells by triggering endocytosis following receptor engagement. However, the mechanisms by which non-enveloped viruses escape the endosome are poorly understood. Here we present near-atomic-resolution cryo-electron microscopy structures for feline calicivirus both undecorated and labelled with a soluble fragment of its cellular receptor, feline junctional adhesion molecule A. We show that VP2, a minor capsid protein encoded by all caliciviruses

Indexed as

Cryoelectron MicroscopyVirus AssemblyAnimalsCalicivirus, FelineCapsid ProteinsCatsCell LineEndosomesGenome, ViralHydrophobic and Hydrophilic InteractionsJunctional Adhesion Molecule AModels, MolecularReceptors, VirusStatic ElectricityVirionCapsid ProteinsJunctional Adhesion Molecule AReceptors, Virus

Identifiers

PMID30626974
OpenAlexW2910094524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.