ArticleMolecular psychiatry2020
New roles for dopamine D
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In one paragraph
Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Dopaminergic modulation of pancreatic beta-cell insulin secretion and implications for antipsychotic-induced glucose dysregulation: a systematic review and meta-analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Pooled it
- Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Beyond Pleasure: Unraveling the Multifaceted Role of Dopamine in Obesity and Metabolic Regulation.Current obesity reports · 2026Review
- Multi-Target Cardioprotective Potential of Garcinia indica Choisy in Olanzapine-Induced Cardiometabolic Dysregulation: Evidence From Computational and Experimental Insights in H9c2(2-1) Cells.Chemistry & biodiversity · 2026Article
- A Novel Mouse Model of Sympathoadrenal Catecholamine Deficiency by Ablation of the Tyrosine Hydroxylase Gene With Slc6a4-Cre.Journal of neurochemistry · 2026Article
- No Evidence of Association Between Human 24-Hour Urinary Dopamine and Weight, BMI or Glucose Homeostasis in a Retrospective Analysis.International journal of endocrinology and metabolism · 2026Article
- GPCR Biased Signaling in Metabolism.Handbook of experimental pharmacology · 2026Review
- Effect of pergolide treatment on insulin dysregulation in horses and ponies with pituitary pars intermedia dysfunction.Equine veterinary journal · 2025Article
- Brain insulin signaling restores deficits in striatal dopamine release in overweight male mice with preexisting low D2-receptor expression.bioRxiv : the preprint server for biology · 2025Article
- Diabetes mellitus secondary to endocrine diseases: a position statement of the working group of the club of the Italian society of endocrinology (SIE)-Nutrition hormones and metabolism.Journal of endocrinological investigation · 2025Review
- Overexpression of the short isoform of the dopamine D2 receptor causes diet-induced obesity and hyperglycemia in mice.Journal of neuroendocrinology · 2025Article
- Article
- Biological mechanisms of dopamine DFrontiers in endocrinology · 2025Article
- First exposure to second-generation antipsychotics alters gut microbiota and metabolic profiles in patients with glucose-lipid metabolism disorders.Frontiers in psychiatry · 2025Article
- Glucose sensing and homeostasis by adipocyte GPCR.Frontiers in endocrinology · 2025Review
- Changes in pancreatic levodopa uptake in patients with obesity and new-onset type 2 diabetes: an 18F-FDOPA PET-CT study.Frontiers in endocrinology · 2025Article
- Validation of radiolabelled exendin for beta cell imaging by ex vivo autoradiography and immunohistochemistry of human pancreas.EJNMMI research · 2024Article
- Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia.Diabetes · 2024Article
- Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome.JCI insight · 2024Article
- Evidence for dopamine production and distribution of dopamine D2 receptors in the equine gastrointestinal mucosa and pancreas.PloS one · 2024Article
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 1 country.
Zachary J FarinoDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Travis J MorgensternDepartment of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Antonella MaffeiDivision of Endocrinology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Matthias QuickDepartment of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Alain J De SolisDivision of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA.
Pattama WiriyasermkulDepartment of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Robin J FreybergDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Despoina AslanoglouDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Denise SorisioDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Benjamin P InbarDepartment of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
R Benjamin FreeMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Prashant DonthamsettiDepartment of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Eugene V MosharovDepartment of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Christoph KellendonkDepartment of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Gary J SchwartzDepartments of Medicine and Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0003-0446-5553
David R SibleyMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Claudia SchmaussDepartment of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Lori M ZeltserDivision of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, NY, USA.
Holly MooreDepartment of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Paul E HarrisDivision of Endocrinology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Jonathan A JavitchDepartment of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.
Zachary FreybergDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. freyberg@pitt.edu.ORCID http://orcid.org/0000-0001-6460-0118
Columbia University · USNew York Psychoanalytic Society and Institute · USUniversity of Pittsburgh · USNational Institutes of Health · USAlbert Einstein College of Medicine · US
Funding
Molecular And Pharmacological Studies Of Dopamine ReceptorsZIANS002263 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SIBLEY, DAVID · 2009 to 2025
$37.4MStructure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0MTraining in Schizophrenia and Psychotic Disorders: From Animal Models to PatientsT32MH018870 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Guillermo Horga, Christoph Kellendonk · 1988 to 2026
$9.8MMedium Spiny Neuron Excitability and MotivationR01MH093672 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2011 to 2020
$5.0MInteraction between DA, alpha-Synuclein and Chaperone-Mediated AutophagyR01NS075222 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOSHAROV, EUGENE V · 2011 to 2015
$1.7MRevealing Novel Mechanisms of Amphetamine Action in a Drosophila ModelK08DA031241 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI FREYBERG, ZACHARY · 2011 to 2015
$931kDevelopment of an Optogenetic Toolkit to Dissect Dopamine Receptor Function in vivoF32DA044696 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DONTHAMSETTI, PRASHANT CHANDRA · 2017 to 2019
$178kNIDA NIH HHS F32 DA044696NIDA NIH HHS K08 DA031241NIMH NIH HHS R01 MH054137NIMH NIH HHS R01 MH093672NIMH NIH HHS T32 MH018870NINDS NIH HHS R01 NS075222
Abstract
Although long-studied in the central nervous system, there is increasing evidence that dopamine (DA) has important roles in the periphery including in metabolic regulation. Insulin-secreting pancreatic β-cells express the machinery for DA synthesis and catabolism, as well as all five DA receptors. In these cells, DA functions as a negative regulator of glucose-stimulated insulin secretion (GSIS), which is mediated by DA D
Indexed as
DopamineInsulin-Secreting CellsAnimalsInsulin SecretionMiceReceptors, Dopamine D2Receptors, Dopamine D3DopamineReceptors, Dopamine D2Receptors, Dopamine D3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.