ArticleScientific reports2019
Microbial embryonal colonization during pipefish male pregnancy.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 81 citations in OpenAlex.
- Parental fasting effects on offspring immune gene expression, epigenetic patterns, and gut microbiota in a species with male pregnancy (Syngnathus typhle).BMC biology · 2026Article
- Signatures and likely sources of the male pregnancy microbiome in wild bay pipefish (Syngnathus leptorhynchus).Animal microbiome · 2025Article
- Paternal microbiota manipulation influences offspring microbial colonization and development in a sex role-reversed pipefish.Scientific reports · 2025Article
- Surviving on Limited Resources: Effects of Caloric Restriction on Growth, Gene Expression and Gut Microbiota in a Species With Male Pregnancy (Hippocampus erectus).Molecular ecology · 2025Article
- Changes to the reproductive microbiome of the brood pouch during male pregnancy in seahorses (Hippocampus abdominalis).Reproduction (Cambridge, England) · 2025Article
- Environmental microbial reservoir influences the bacterial communities associated with Hydra oligactis.Scientific reports · 2024Article
- Parent-Specific Transgenerational Immune Priming Enhances Offspring Defense-Unless Heat Stress Negates It All.Ecology and evolution · 2024Article
- The source of microbial transmission influences niche colonization and microbiome development.Proceedings. Biological sciences · 2024Article
- Interwoven processes in fish development: microbial community succession and immune maturation.PeerJ · 2024Review
- Microbial influence on the larval survival of Japanese eel Anguilla japonica: Antibiotic-mediated alterations and biomarker isolation.PloS one · 2024Article
- Seahorse Male Pregnancy as a Model System to Study Pregnancy, Immune Adaptations, and Environmental Effects.International journal of molecular sciences · 2023Review
- Shifts in gut microbiome across five decades of repeated guppy translocations in Trinidadian streams.Proceedings. Biological sciences · 2022Article
- Hepcidin Gene Co-Option Balancing Paternal Immune Protection and Male Pregnancy.Frontiers in immunology · 2022Article
- Intergenerational Transfer of Persistent Bacterial Communities in Female Nile Tilapia.Frontiers in microbiology · 2022Article
- Potential lineage transmission within the active microbiota of the eggs and the nauplii of the shrimpPeerJ · 2021Article
- In the beginning: egg-microbe interactions and consequences for animal hosts.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
While originally acquired from the environment, a fraction of the microbiota is transferred from parents to offspring. The immune system shapes the microbial colonization, while commensal microbes may boost host immune defences. Parental transfer of microbes in viviparous animals remains ambiguous, as the two transfer routes (transovarial vs. pregnancy) are intermingled within the maternal body. Pipefishes and seahorses (syngnathids) are ideally suited to disentangle transovarial microbial transfer from a contribution during pregnancy due to their maternal egg production and their unique male pregnancy. We assessed the persistency and the changes in the microbial communities of the maternal and paternal reproductive tracts over proceeding male pregnancy by sequencing microbial 16S rRNA genes of swabs from maternal gonads and brood pouches of non-pregnant and pregnant fathers. Applying parental immunological activation with heat-killed bacteria, we evaluated the impact of parental immunological status on microbial development. Our data indicate that maternal gonads and paternal brood pouches harbor distinct microbial communities, which could affect embryonal development in a sex-specific manner. Upon activation of the immune system, a shift of the microbial community was observed. The activation of the immune system induced the expansion of microbiota richness during late pregnancy, which corresponds to the time point of larval mouth opening, when initial microbial colonization must take place.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.