Evidence map›Paper›PMID 30626873›Full record

ArticleNature communications2019

Ultrasonic sculpting of virtual optical waveguides in tissue.

Maysamreza Chamanzar, Matteo Giuseppe Scopelliti, Julien Bloch, Ninh Do, Minyoung Huh, Dongjin Seo, Jillian Iafrati, Vikaas S Sohal, Mohammad-Reza Alam, Michel M Maharbiz

Abstract read
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In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Maysamreza ChamanzarElectrical and Computer Engineering Department, Carnegie Mellon University, Pittsburgh, 15213, PA, USA. mchamanzar@cmu.edu.
Matteo Giuseppe ScopellitiElectrical and Computer Engineering Department, Carnegie Mellon University, Pittsburgh, 15213, PA, USA.
Julien BlochMechanical Engineering Department, University of California, 94720, Berkeley, CA, USA.
Ninh DoMechanical Engineering Department, University of California, 94720, Berkeley, CA, USA.
Minyoung HuhElectrical Engineering and Computer Science Department, University of California, Berkeley, 94720, CA, USA.
Dongjin SeoElectrical Engineering and Computer Science Department, University of California, Berkeley, 94720, CA, USA.
Jillian IafratiDepartment of Psychiatry, University of California, San Francisco, 94103, CA, USA.
Vikaas S SohalDepartment of Psychiatry, University of California, San Francisco, 94103, CA, USA.
Mohammad-Reza AlamMechanical Engineering Department, University of California, 94720, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-9730-0717
Michel M MaharbizElectrical Engineering and Computer Science Department, University of California, Berkeley, 94720, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optical imaging and stimulation are widely used to study biological events. However, scattering processes limit the depth to which externally focused light can penetrate tissue. Optical fibers and waveguides are commonly inserted into tissue when delivering light deeper than a few millimeters. This approach, however, introduces complications arising from tissue damage. In addition, it makes it difficult to steer light. Here, we demonstrate that ultrasound can be used to define and steer the trajectory of light within scattering media by exploiting local pressure differences created by acoustic waves that result in refractive index contrasts. We show that virtual light pipes can be created deep into the tissue (>18 scattering mean free paths). We demonstrate the application of this technology in confining light through mouse brain tissue. This technology is likely extendable to form arbitrary light patterns within tissue, extending both the reach and the flexibility of light-based methods.

Indexed as

AnimalsBrainComputer SimulationImaging, Three-DimensionalMiceMice, Inbred C57BLModels, BiologicalOptical ImagingUltrasonography

Identifiers

PMID30626873
PMCPMC6327026

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.