ArticleNature communications2019
Costless metabolic secretions as drivers of interspecies interactions in microbial ecosystems.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
173 citing papers in PubMed.
- Effects of Prebiotic Yeast Mannan on Gut Health and Sleep Quality in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study.Nutrients · 2023Trial
- Decoding microbial metabolic complementarity from individual traits to community structuring.Ecology · 2026Article
- The Effects of Vitamin DAnimals : an open access journal from MDPI · 2026Article
- Article
- Specificity and longevity of a bacterial interspecies mutual cooperation benefiting organic micropollutant biodegradation.Applied and environmental microbiology · 2026Article
- Bacterial degradation of a plant toxin and nutrient competition with commensals trade off to constrain pathogen growth.mSystems · 2026Article
- Biofilm-mediated antibiotic cross-protection:Microbiology spectrum · 2026Article
- Quartet: Disentangling positive and negative components of microbial interactions.PLoS computational biology · 2026Article
- Therapeutic Potential of Ginkgolic Acid C17:1 in Modulating PTEN/mtDNA/TLR9 Axis for Alleviating Chronic Pseudomonas Aeruginosa Infection in Bronchiectasis.Iranian journal of biotechnology · 2026Article
- Low initial metabolite production enhances stability in syntrophic bacterial consortia.Communications biology · 2026Article
- The network structure of cross-feeding impacts microbial community diversity under growth-inhibiting stresses.Nature communications · 2026Article
- Limits to the evolution of metabolic dependency in spatially structured microbial communities.iScience · 2026Article
- 4-Hydroxyphenanthrene exacerbates obesity by altering gut microbiota and bile acid metabolism.Nature communications · 2026Article
- The mechanism and application of the selenium hyperaccumulator Cardamine hupingshanensis: status and challenges.Annals of botany · 2026Review
- Differential survival and tolerance mechanisms ofApplied and environmental microbiology · 2026Article
- Cross-feeding options define genome evolution and community assembly of deep groundwater microbiome.Environmental microbiome · 2026Article
- Stoichiometric analysis of microbial communities links function, structure, and biomass carrying capacity.The ISME journal · 2026Review
- Acidifying bacteria inhibit pathogenic bacteria more strongly with increasing glucose.The ISME journal · 2026Article
- Mechanisms for the formation and maintenance of microhabitat self-organization in the root system of orchid.Frontiers in genetics · 2026Review
- Real-time simultaneous monitoring of multiple analytes in bacterial cultures.Applied and environmental microbiology · 2025Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Metabolic exchange mediates interactions among microbes, helping explain diversity in microbial communities. As these interactions often involve a fitness cost, it is unclear how stable cooperation can emerge. Here we use genome-scale metabolic models to investigate whether the release of "costless" metabolites (i.e. those that cause no fitness cost to the producer), can be a prominent driver of intermicrobial interactions. By performing over 2 million pairwise growth simulations of 24 species in a combinatorial assortment of environments, we identify a large space of metabolites that can be secreted without cost, thus generating ample cross-feeding opportunities. In addition to providing an atlas of putative interactions, we show that anoxic conditions can promote mutualisms by providing more opportunities for exchange of costless metabolites, resulting in an overrepresentation of stable ecological network motifs. These results may help identify interaction patterns in natural communities and inform the design of synthetic microbial consortia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.