Evidence map›Paper›PMID 30626837›Full record

ArticleInternal medicine (Tokyo, Japan)2019

Development of Propionibacterium acnes-associated Sarcoidosis During Etanercept Therapy.

Takuma Isshiki, Hisayo Matsuyama, Susumu Sakamoto, Naoko Honma, Tetuo Mikami, Kazutoshi Shibuya, Yoshinobu Eishi, Sakae Homma

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Potential Association ofMicroorganisms · 2023
    Review
  5. The Role ofMicroorganisms · 2022
    Review
  6. Immunohistochemical Detection ofMicroorganisms · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Takuma IsshikiDepartment of Respiratory Medicine, Toho University Omori Medical Centre, Japan.
Hisayo MatsuyamaDepartment of Respiratory Medicine, Toho University Omori Medical Centre, Japan.
Susumu SakamotoDepartment of Respiratory Medicine, Toho University Omori Medical Centre, Japan.
Naoko HonmaDepartment of Pathology, Toho University Omori Medical Centre, Japan.
Tetuo MikamiDepartment of Pathology, Toho University Omori Medical Centre, Japan.
Kazutoshi ShibuyaDepartment of Pathology, Toho University Omori Medical Centre, Japan.
Yoshinobu EishiDepartment of Human Pathology, Tokyo Medical and Dental University, Japan.
Sakae HommaDepartment of Respiratory Medicine, Toho University Omori Medical Centre, Japan.
Toho University · JPToho University Omori Medical Center · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although numerous recent studies have reported the development of sarcoidosis in patients treated with tumor necrosis factor alpha (TNF-α) inhibitors, it is unclear whether the pathogenesis of drug-induced sarcoidosis is identical to that of spontaneous sarcoidosis. We herein present the case of a patient who developed sarcoidosis 6 months after the introduction of etanercept as treatment for rheumatoid arthritis. Typical clinical symptoms with noncaseating epithelioid granulomas detected in a mediastinal lymph node specimen were consistent with the diagnosis of sarcoidosis. Immunohistochemistry revealed Propionibacterium acnes in the noncaseating granulomas. The present findings suggest that Propionibacterium acnes is a cause of sarcoidosis, even when the disease is induced by TNF-α inhibitors.

Indexed as

Anti-Asthmatic AgentsArthritis, RheumatoidEtanerceptFemaleGranulomaHumansLymph NodesMaleMediastinumMiddle AgedPropionibacterium acnesSarcoidosisTumor Necrosis Factor-alphaAnti-Asthmatic AgentsEtanerceptTumor Necrosis Factor-alphaetanerceptPropionibacterium acnessarcoidosisTNF-α

Identifiers

PMID30626837
PMCPMC6548918
OpenAlexW2910797320

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.