Evidence map›Paper›PMID 30626725›Full record

ArticleBioscience reports2019

The morphology and histology study on rabbit degenerated medial meniscus after posterior cruciate ligament rupture.

Zhenhan Deng, Wei Luo, Shanshan Gao, Zhan Liao, Yihe Hu, Hongbo He, Can Zhang, Kanghua Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhenhan DengDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0003-0522-8269
Wei LuoDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shanshan GaoDepartment of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, U.S.A.
Zhan LiaoDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yihe HuDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hongbo HeDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Can ZhangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China zhangcan007@csu.edu.cn likanghua@csu.edu.cn.ORCID 0000-0002-4239-8593
Kanghua LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China zhangcan007@csu.edu.cn likanghua@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The morphology and histology changes in the medial meniscus after posterior cruciate ligament (PCL) rupture are poorly understood. Forty-eight rabbits were divided into matched mode pairs; each rabbit had an experimental side, in which the PCL was transacted, and a control side. At the 4, 8, 16 and 24 weeks after the PCL transection, each of the 12 rabbits was killed. Histology was performed to detect the expression of the tissue inhibitors of metalloproteinases-1 (TIMP-1), matrix metalloproteinase (MMP)-1 and MMP-13 in the medial meniscus. We found that medial meniscus displayed significant degenerative characteristics in morphology. The histological evaluation of the degeneration found that the expression levels of TIMP-1, MMP-1 and MMP-13 in the medial meniscus were higher in the experiment side than those in the control side (

Indexed as

AnimalsDisease Models, AnimalGene Expression RegulationHumansKnee InjuriesMatrix Metalloproteinase 1Matrix Metalloproteinase 13Menisci, TibialOsteoarthritisPosterior Cruciate LigamentRabbitsTissue Inhibitor of Metalloproteinase-1Matrix Metalloproteinase 1Matrix Metalloproteinase 13Tissue Inhibitor of Metalloproteinase-1medial meniscusMMP-1MMP-13PCL ruptureTIMP-1

Identifiers

PMID30626725
PMCPMC6350045

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.