Evidence map›Paper›PMID 30626634›Full record

Observational studyClinical chemistry2019

Cell-Free

Maria Jung, Jörg Ellinger, Heidrun Gevensleben, Isabella Syring, Christine Lüders, Luka de Vos, Svenja Pützer, Friedrich Bootz, Jennifer Landsberg, Glen Kristiansen and 1 more

Open access · bronzeAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Small-scale external quality assessment of methylatedClinical chemistry and laboratory medicine · 2026
    Article
  2. Current Status and Future Perspectives of Molecular Residual Disease Testing in Genitourinary Cancers.International journal of urology : official journal of the Japanese Urological Association · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Management of Renal Cell Carcinoma: Promising Biomarkers and the Challenges to Reach the Clinic.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Review
  10. Article
  11. Article
  12. DNA Methylation Analysis of theJournal of oncology · 2023
    Article
  13. Review
  14. Article
  15. Epigenetic Biomarkers of Renal Cell Carcinoma for Liquid Biopsy Tests.International journal of molecular sciences · 2021
    Review
  16. Review
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Maria JungInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
Jörg EllingerDepartment of Urology, University Hospital Bonn, Bonn, Germany.
Heidrun GevenslebenInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
Isabella SyringDepartment of Urology, University Hospital Bonn, Bonn, Germany.
Christine LüdersInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
Luka de VosDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany.
Svenja PützerInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
Friedrich BootzDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany.
Jennifer LandsbergDepartment of Dermatology, University Hospital Bonn, Bonn, Germany.
Glen KristiansenInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
Dimo DietrichDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany; dimo.dietrich@gmail.com.
University Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNovel targeted treatments and immunotherapies have substantially changed therapeutic options for advanced and metastatic renal cell carcinomas (RCCs). However, accurate diagnostic tests for the identification of high-risk patients are urgently needed. Here, we analyzed SHOX2 mRNA expression in RCC tissues and

methodsThe clinical performance of

results

conclusionsPretherapeutic

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Renal CellCell-Free Nucleic AcidsCohort StudiesDNADNA MethylationFeasibility StudiesFemaleHomeodomain ProteinsHumansKidney NeoplasmsMaleMiddle AgedBiomarkers, TumorCell-Free Nucleic AcidsDNAHomeodomain ProteinsSHOX2 protein, human

Identifiers

PMID30626634
OpenAlexW2909962731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.