ArticleG3 (Bethesda, Md.)2019
Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14.
Open access · goldAbstract read
In one paragraph
Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes.The Journal of allergy and clinical immunology · 2021Pooled it
- Multitrait analysis of genome-wide association studies expands eosinophilic esophagitis genetic susceptibility and polygenic risk scores.The Journal of allergy and clinical immunology · 2026Article
- Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Th2 Cytokines Reshape the Transcriptome: Insights from a Canine Organoid Model of Atopic Dermatitis.International journal of molecular sciences · 2026Article
- Overlap of Genomic and Transcriptomic Genes Identified in Familial Eosinophilic Esophagitis.Gastroenterology · 2025Article
- Update on the genetics of allergic diseases.The Journal of allergy and clinical immunology · 2025Review
- Unravelling the pathogenesis of Eosinophilic Esophagitis from genetic predisposition to environmental triggers.Clinical and experimental immunology · 2025Review
- A synthesis and subgroup analysis of the eosinophilic esophagitis tissue transcriptome.The Journal of allergy and clinical immunology · 2024Article
- Systematic identification of genotype-dependent enhancer variants in eosinophilic esophagitis.American journal of human genetics · 2024Article
- IL-13-induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2023Article
- Scientific journey to the first FDA-approved drug for eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2022Article
- Butyrate and propionate restore interleukin 13-compromised esophageal epithelial barrier function.Allergy · 2022Article
- Examining the Role of Type 2 Inflammation in Eosinophilic Esophagitis.Gastro hep advances · 2022Review
- Molecular Mechanisms of Eosinophilic Esophagitis.International journal of molecular sciences · 2021Review
- Desmoplakin and periplakin genetically and functionally contribute to eosinophilic esophagitis.Nature communications · 2021Observational
- Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets.Frontiers in physiology · 2021Review
- Pathogenesis of Eosinophilic Esophagitis: A Comprehensive Review of the Genetic and Molecular Aspects.International journal of molecular sciences · 2020Review
- Elevated levels of calpain 14 in nasal tissue in chronic rhinosinusitis.ERJ open research · 2020Article
- Article
- The genetic etiology of eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 2 institutions in 1 country.
Daniel E MillerCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Carmy ForneyCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Mark RochmanDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Stacey CranertCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Jeffery HabelDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Jeffrey RymerDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Arthur LynchCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Connor SchroederCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Josh LeeCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Amber SauderCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Quinton SmithCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Mehak ChawlaCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Michael P TrimarchiDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Xiaoming LuCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.ORCID 0000-0002-0830-2826
Ellen FjellmanCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Michael BrusilovskyDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Artem BarskiDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Stephen WaggonerCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.
Matthew T WeirauchCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.ORCID 0000-0001-7977-9122
Marc E RothenbergDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.ORCID 0000-0001-9790-6332
Leah C KottyanCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229 Leah.Kottyan@cchmc.org.ORCID 0000-0003-3979-2220
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · US
Funding
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4MTissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7MGenetic and Immunological Dissection of Eosinophilic EsophagitisR01AI124355 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Marc E. Rothenberg · 2015 to 2026
$5.9MBetter Outcomes for Children: Promoting Excellence in Healthcare Genomics to Inform PolicyU01HG008666 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI HARLEY, JOHN BARKER · 2015 to 2019
$4.2MBinding of Epstein Barr Virus EBNA2 Unifies Multiple Sclerosis Genetic MechanismsR01NS099068 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan, Matthew Tyson Weirauch · 2017 to 2026
$4.2MA revolutionary vaccine approach to prevent HIV infection in substance abuseDP1DA038017 · NIDA · CINCINNATI CHILDRENS HOSP MED CTR · PI WAGGONER, STEPHEN N. · 2014 to 2018
$3.9MRegulation of Gastrointestinal EosinophilsR37AI045898 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI ROTHENBERG, MARC E. · 2010 to 2019
$3.6MDirect Epigenetic Reprogramming of T CellsDP2GM119134 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI BARSKI, ARTEM · 2015 to 2015
$2.3MMechanisms of genetic risk at 2p23 in Eosinophilic EsophagitisR01DK107502 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTYAN, LEAH CLAIRE · 2016 to 2020
$1.8MEffect of disease-associated genetic variants on viral protein DNA bindingR21HG008186 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI WEIRAUCH, MATTHEW TYSON · 2015 to 2017
$464kNHGRI NIH HHS R21 HG008186NHGRI NIH HHS U01 HG008666NIAID NIH HHS R01 AI124355NIAID NIH HHS R37 AI045898NIAMS NIH HHS P30 AR070549NIDA NIH HHS DP1 DA038017NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK107502NIGMS NIH HHS DP2 GM119134NINDS NIH HHS R01 NS099068
Abstract
Eosinophilic esophagitis (EoE) is a chronic, food-driven allergic disease resulting in eosinophilic esophageal inflammation. We recently found that EoE susceptibility is associated with genetic variants in the promoter of
Indexed as
Gene Expression RegulationPolymorphism, Single NucleotideCalpainCell LineEosinophilic EsophagitisEpithelial CellsGenetic Predisposition to DiseaseHumansInflammationInterleukin-13Interleukin-4Promoter Regions, GeneticSTAT6 Transcription FactorCalpainCAPN14 protein, humanIL4 protein, humanInterleukin-13Interleukin-4STAT6 protein, humanSTAT6 Transcription FactorCAPN14Eosinophilic EsophagitisGenetics of ImmunityIL-13IL-4STAT6
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.