ArticleCancer discovery2019
Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Cancer discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 197 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 3 pooled it
13.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
197 citing papers in PubMed, 3 syntheses or guidelines pooled it, 315 citations in OpenAlex.
- The Relationship between Statin Intake and Risk of Pancreatic Cancer: A Systematic Review and Meta-analysis.Current drug research reviews · 2025Pooled it
- Statins and the risk of pancreatic cancer: A systematic review and meta-analysis of 2,797,186 patients.Cardiology journal · 2024Pooled it
- Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review.Signal transduction and targeted therapy · 2023Pooled it
- Research progress on ATP-citrate lyase and its inhibitors: a metabolic-epigenetic perspective.Journal of enzyme inhibition and medicinal chemistry · 2026Review
- Cholesterol metabolism dysregulation in eyelid sebaceous gland carcinoma and its clinical significance.Indian journal of ophthalmology · 2026Article
- Blocking L-carnitine synthesis by meldonium prolongs the survival in mice with pancreatic cancer.iScience · 2026Article
- The interplay between lipid metabolism, cancer progression and anti-cancer immunity.Experimental & molecular medicine · 2026Review
- Obesity and diabetes associated with dysregulation of mevalonate pathway markers and progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor.Stem cell research & therapy · 2026Article
- ISL@mTOMV nanoparticles: a promising approach for VM-targeted therapy in breast cancer.Journal of nanobiotechnology · 2026Article
- Transcriptomic regulation of pancreatic acinar cell homeostasis and plasticity.Biochemical Society transactions · 2026Review
- Extracellular Vesicle-Transferred ATP-Citrate Lyase Induces Monocyte Differentiation Toward Tumor-Associated Macrophages and Fuels Hepatocellular Carcinoma Progression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Coke Oven Emission Exposure Triggers Malignant Transformation of Lung Epithelial Cells byEnvironment & health (Washington, D.C.) · 2026Article
- Acetyl-coenzyme A synthetase 2-mediated acetyl-coenzyme A accumulation promotes mitophagy and tumor growth via increased H3K27ac in hepatitis B virus-related hepatocellular carcinoma.Clinical and molecular hepatology · 2026Article
- Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment.Molecular cancer · 2026Review
- Acetyl-CoA synthase 1 mediates metabolic reprogramming to promote proliferation and metastasis of osteosarcoma.Journal of orthopaedic translation · 2026Article
- Mevalonate pathway in pancreatic ductal adenocarcinoma: Mechanisms driving metabolic and cellular plasticity.Cancer pathogenesis and therapy · 2026Review
- Navigating the complexities of ferroptosis in pancreatic ductal adenocarcinoma: roles, mechanisms and potential applications.Cell death discovery · 2026Review
- Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma.Frontiers in cell and developmental biology · 2026Article
- Exploring Lipid Metabolic Reprogramming: Mechanistic Insights and Implications for Tumor Radiotherapy.International journal of biological sciences · 2026Review
- Reprogramming of cholesterol sensing in epithelial cells supports pancreatic inflammation.Molecular metabolism · 2026Article
137 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
18 authors at 4 institutions in 1 country.
Alessandro CarrerDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Sophie TrefelyDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-3816-6869
Steven ZhaoDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Sydney L CampbellDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Robert J NorgardDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Kollin C SchultzDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Simone SidoliEpigenetics Institute, Departments of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Joshua L D ParrisDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Hayley C AffrontiDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-9751-0629
Sharanya SivanandDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Shaun EgolfDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Yogev SelaDepartment of Medicine, Gastroenterology Division, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Marco TrizzinoThe Wistar Institute, Gene Expression and Regulation Program, Philadelphia, Pennsylvania.
Alessandro GardiniThe Wistar Institute, Gene Expression and Regulation Program, Philadelphia, Pennsylvania.
Benjamin A GarciaEpigenetics Institute, Departments of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Nathaniel W SnyderA.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania.ORCID 0000-0001-5643-8747
Ben Z StangerA.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania.
Kathryn E WellenDepartment of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. wellenk@upenn.edu.
UPMC Hillman Cancer Center · USUniversity of Pennsylvania · USDrexel University · USThe Wistar Institute · US
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MShared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI LEWIS, PETER W · 2015 to 2024
$17.6MPenn Dermatology Research Training ProgramT32AR007465 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, David Joel Margolis · 1986 to 2026
$9.0MUPenn Post Baccalaureate Research Education Program.R25GM071745 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BHOJ, ELIZABETH JOYCE, KESSLER, DANIEL S · 2005 to 2024
$6.4MViral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4MRole of acetyl-CoA in linking cancer cell metabolism and epigeneticsR01CA174761 · NCI · UNIVERSITY OF PENNSYLVANIA · PI WELLEN, KATHRYN ELAINE · 2014 to 2024
$3.6MDefining an acetyl-CoA sensing mechanism as a form of inter-organelle communication in cancerR01CA228339 · NCI · UNIVERSITY OF PENNSYLVANIA · PI WELLEN, KATHRYN ELAINE · 2018 to 2022
$1.9MUnderstanding the Role of Combinatorial Histone PTM PatternsR01GM110174 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GARCIA, BENJAMIN A · 2014 to 2017
$1.3MLeveraging polyamine metabolic stress as a novel therapy for prostate cancerK00CA212455 · NCI · UNIVERSITY OF PENNSYLVANIA · PI AFFRONTI, HAYLEY · 2018 to 2020
$218kMetabolism of propionic acidR03HD092630 · NICHD · DREXEL UNIVERSITY · PI SNYDER, NATHANIEL W. · 2017 to 2018
$157kRole of the hexosamine biosynthesis pathway in pancreatic cancer.F31CA217070 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CAMPBELL, SYDNEY · 2017 to 2019
$134kMetabolic rewiring regulates cancer growth and tumor-associated immune responsesF99CA222741 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHAO, STEVEN · 2017 to 2018
$77kNCI NIH HHS F31 CA217070NCI NIH HHS F99 CA222741NCI NIH HHS K00 CA212455NCI NIH HHS P01 CA196539NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA174761NCI NIH HHS R01 CA228339NIAID NIH HHS R01 AI118891NIAMS NIH HHS T32 AR007465NICHD NIH HHS R03 HD092630NIGMS NIH HHS R01 GM110174NIGMS NIH HHS R25 GM071745
Abstract
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring
Indexed as
AcetylationAcetyl Coenzyme AAcinar CellsAnimalsCarcinogenesisCarcinoma, Pancreatic DuctalCell ProliferationFemaleGenes, rasHeterograftsHistonesHumansMaleMice, Inbred C57BLMice, KnockoutMice, TransgenicAcetyl Coenzyme AHistones
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What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.