ArticleArthritis research & therapy2019
Interactions between serum urate-associated genetic variants and sex on gout risk: analysis of the UK Biobank.
Article in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Risk of Ossification of the Posterior Longitudinal Ligament (OPLL) following gout diagnosis: a nationwide cohort study.International orthopaedics · 2026Article
- Using Multi-Omics Methods to Understand Gouty Arthritis.Current rheumatology reviews · 2026Review
- Association of rare and common genetic variants in MOCOS with inadequate response to allopurinol.Rheumatology (Oxford, England) · 2024Article
- The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies.Nature reviews. Rheumatology · 2024Review
- Polymorphism rs3733591 of theFrontiers in genetics · 2024Article
- The Evolving Landscape of Gout in the Female: A Narrative Review.Gout, urate, and crystal deposition disease · 2023Article
- Susceptibility genes of hyperuricemia and gout.Hereditas · 2022Review
- An association study of ABCG2 rs2231142 on the concentrations of allopurinol and its metabolites.Clinical and translational science · 2022Article
- Impact of adiposity on risk of female gout among those genetically predisposed: sex-specific prospective cohort study findings over >32 years.Annals of the rheumatic diseases · 2022Article
- Genetic assessment of hyperuricemia and gout in Asian, Native Hawaiian, and Pacific Islander subgroups of pregnant women: biospecimens repository cross-sectional study.BMC rheumatology · 2022Article
- Managing Gout in Women: Current Perspectives.Journal of inflammation research · 2022Review
- Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants.Pharmacogenomics and personalized medicine · 2022Article
- Urate transport in health and disease.Best practice & research. Clinical rheumatology · 2021Review
- Serum urate and lung cancer: a cohort study and Mendelian randomization using UK Biobank.Respiratory research · 2021Observational
- Taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism.Molecular medicine (Cambridge, Mass.) · 2021Article
- Polymorphisms of the genesF1000Research · 2021Article
- Sex Differences in Urate Handling.International journal of molecular sciences · 2020Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSex-specific differences in the effect of genetic variants on serum urate levels have been described. The aim of this study was to systematically examine whether serum urate-associated genetic variants differ in their influence on gout risk in men and women.
methodsThis research was conducted using the UK Biobank Resource. Thirty single nucleotide polymorphisms (SNPs) associated with serum urate were tested for their association with gout in men and women of European ancestry, aged 40-69 years. Gene-sex interactions for gout risk were analysed using an interaction analysis in logistic regression models.
resultsGout was present in 6768 (4.1%) men and 574 (0.3%) women, with an odds ratio (95% confidence interval) for men 13.42 (12.32-14.62) compared with women. In men, experiment-wide association with gout was observed for 21 of the 30 serum urate-associated SNPs tested, and in women for three of the 30 SNPs. Evidence for gene-sex interaction was observed for ABCG2 (rs2231142) and PDZK1 (rs1471633), with the interaction in ABCG2 driven by an amplified effect in men and in PDZK1 by an absence of effect in women. Similar findings were observed in a sensitivity analysis which excluded pre-menopausal women. For the other SNPs tested, no significant gene-sex interactions were observed.
conclusionsIn a large population of European ancestry, ABCG2 and PDZK1 gene-sex interactions exist for gout risk, with the serum urate-raising alleles exerting a greater influence on gout risk in men than in women. In contrast, other serum urate-associated genetic variants do not demonstrate significant gene-sex interactions for gout risk.
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