ArticleJournal of neuroinflammation2019
CSF inflammatory markers differ in gram-positive versus gram-negative shunt infections.
Article in Journal of neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Machine learning models for predicting cerebrospinal fluid bacterial culture outcomes in post-neurosurgical meningitis-development and temporal three-year validation.Archives of microbiology · 2026Article
- CSF Leukocytes in Intracranial Infections: Diagnostic, Mechanistic, and Therapeutic Insights for Neurocritical Care.Cellular and molecular neurobiology · 2026Review
- Article
- Complications of ventriculoperitoneal shunts: Infection and exposure in hydrocephalus patients: A case series.Surgical neurology international · 2024Article
- Paediatric ventriculoperitoneal shunt failures: 12-year experience from a Singapore children's hospital.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Bacteria commonly associated with central nervous system catheter infections elicit distinct CSF proteome signatures.Frontiers in neurology · 2023Article
- Cerebrospinal Fluid Shunt Infections in Children: Do Hematologic and Cerebrospinal Fluid White Cells Examinations Correlate With the Type of Infection?The Pediatric infectious disease journal · 2022Article
- Post-neurosurgical meningitis; gram negative bacilli vs. gram positive cocci.Caspian journal of internal medicine · 2022Article
- Article
- Article
- Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation.Brain communications · 2020Article
- Identification of Potential Cerebrospinal Fluid Biomarkers To Discriminate between Infection and Sterile Inflammation in a Rat Model of Staphylococcus epidermidis Catheter Infection.Infection and immunity · 2019Article
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCerebrospinal fluid (CSF) shunt placement is frequently complicated by bacterial infection. Shunt infection diagnosis relies on bacterial culture of CSF which can often produce false-negative results. Negative cultures present a conundrum for physicians as they are left to rely on other CSF indices, which can be unremarkable. New methods are needed to swiftly and accurately diagnose shunt infections. CSF chemokines and cytokines may prove useful as diagnostic biomarkers. The objective of this study was to evaluate the potential of systemic and CSF biomarkers for identification of CSF shunt infection.
methodsWe conducted a retrospective chart review of children with culture-confirmed CSF shunt infection at Children's Hospital and Medical Center from July 2013 to December 2015. CSF cytokine analysis was performed for those patients with CSF in frozen storage from the same sample that was used for diagnostic culture.
resultsA total of 12 infections were included in this study. Patients with shunt infection had a median C-reactive protein (CRP) of 18.25 mg/dL. Median peripheral white blood cell count was 15.53 × 10
conclusionsThis pilot study is the first to characterize the CSF cytokine profile in patients with CSF shunt infection and supports the distinction of chemokine and cytokine profiles between gram-negative and gram-positive infections. Additionally, it demonstrates the potential of CSF chemokines and cytokines as biomarkers for the diagnosis of shunt infection.
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