ArticleParasites & vectors2019
Fine-scale spatial and temporal dynamics of kdr haplotypes in Aedes aegypti from Mexico.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Chemical control of medically important arthropods in Panama: A systematic literature review of historical efforts.Acta tropica · 2024Pooled it
- Fine-scale spatio-temporal dynamics ofCurrent research in parasitology & vector-borne diseases · 2026Article
- Rising of pyrethroid resistance mutations (kdr) in the dengue vectorFrontiers in public health · 2026Article
- Global distribution and impact of knockdown resistance mutations in Aedes aegypti on pyrethroid resistance.Parasites & vectors · 2025Review
- Widespread geographic distribution of Aedes aegypti (Diptera: Culicidae) kdr variants in Panama.Journal of medical entomology · 2024Article
- Monitoring of pyrethroid resistance in Aedes aegypti: first report of double and triple kdr mutations in Buenos Aires Province.Parasites & vectors · 2024Article
- Insecticide resistance status and mechanisms in Aedes aegypti and Aedes albopictus from different dengue endemic regions of Panama.Tropical medicine and health · 2024Article
- Fine-scale monitoring of insecticide resistance in Aedes aegypti (Diptera: Culicidae) from Sri Lanka and modeling the phenotypic resistance using rational approximation.Parasites & vectors · 2024Article
- Insecticide resistance compromises the control of Aedes aegypti in Bangladesh.Pest management science · 2023Article
- Fine-scale spatial distribution of deltamethrin resistance and population structure of Anopheles funestus and Anopheles arabiensis populations in Southern Mozambique.Malaria journal · 2023Article
- Insecticide resistance in Aedes aegypti from Tapachula, Mexico: Spatial variation and response to historical insecticide use.PLoS neglected tropical diseases · 2021Article
- Review
- Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection inEvolutionary applications · 2021Article
- Spatiotemporal multiple insecticide resistance in Aedes aegypti populations in French Guiana: need for alternative vector control.Memorias do Instituto Oswaldo Cruz · 2021Article
- Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti.Archives of insect biochemistry and physiology · 2020Review
- Spatial variation in the frequency of knockdown resistance genotypes in Florida Aedes aegypti populations.Parasites & vectors · 2020Article
- Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes aegypti.PLoS neglected tropical diseases · 2020Article
- Fine-scale spatial and temporal variations in insecticide resistance in Culex pipiens complex mosquitoes in rural south-eastern Tanzania.Parasites & vectors · 2019Article
- Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti.PLoS neglected tropical diseases · 2019Article
- Seasonal and geographic variation in insecticide resistance in Aedes aegypti in southern Ecuador.PLoS neglected tropical diseases · 2019Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAs resistance to insecticides increases in disease vectors, it has become exceedingly important to monitor populations for susceptibility. Most studies of field populations of Aedes aegypti have largely characterized resistance patterns at the spatial scale of the city or country, which may not be completely informative given that insecticide application occurs at the scale of the house or city block. Phenotypic resistance to pyrethroids dominates in Ae. aegypti, and it has been partially explained by mutations in the voltage-gated sodium channel gene. Here, we assess community-level patterns of four knockdown resistance (kdr) haplotypes (C1534/I1016, F1534/I1016, C1534/V1016 and F1534/V1016) in Ae. aegypti in 24 randomly chosen city blocks from a city in Yucatán State, Mexico, during both the dry and wet season and over two years.
resultsThree of the four haplotypes, C1534/I1016, C1534/V1016 and F1534/V1016 were heterogeneous between city blocks at all four sampling time points, and the double mutant haplotype, C1534/I1016, showed a significant increase following the wet season. The F1534/I1016 haplotype was rarely detected, similar to other studies. However, when haplotype frequencies were aggregated to a coarser spatial scale, the differences in space and time were obscured.
conclusionsOur results provide empirical evidence that the selection of kdr alleles is occurring at fine spatial scales, indicating that future studies should include this scale to better understand evolutionary processes of resistance in natural populations.
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