Evidence map›Paper›PMID 30626349›Full record

ArticleBMC pregnancy and childbirth2019

The contribution of maternal characteristics and cesarean delivery to an increasing trend of severe maternal morbidity.

Stephanie A Leonard, Elliott K Main, Suzan L Carmichael

Abstract read
In one paragraph

Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Extracorporeal Life Support in Pregnancy: A Systematic Review.Journal of the American Heart Association · 2020
    Pooled it
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Stephanie A LeonardDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA. stephanie.leonard@stanford.edu.ORCID http://orcid.org/0000-0001-8213-1319
Elliott K MainDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, California, USA.
Suzan L CarmichaelDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.

Funding

Severe Maternal Morbidity: An Investigation of Racial-Ethnic Disparities, Social Disadvantage & Maternal WeightR01NR017020 · NINR · STANFORD UNIVERSITY · PI SUZAN L CARMICHAEL · 2018 to 2026
$5.2M
Understanding Severe Maternal Morbidity: Predictors, Trends, and DisparitiesF32HD091945 · NICHD · STANFORD UNIVERSITY · PI LEONARD, STEPHANIE A. · 2017 to 2018
$115k
Eunice Kennedy Shriver National Institute of Child Health and Human Development F32HD091945Maternal and Child Health Research Institute, Stanford University (CA) N/ANational Institute of Nursing Research R01NR017020NICHD NIH HHS F32 HD091945NINR NIH HHS R01 NR017020
6 · The paper itself

Abstract

backgroundSevere maternal morbidity - life-threatening childbirth complications - has more than doubled in the United States over the past 15 years, affecting more than 50,000 women (1.4% of deliveries) annually. During this time period, maternal age, obesity, comorbidities, and cesarean delivery also increased and may be related to the rise in severe maternal morbidity. We sought to evaluate: (1) the association of advanced maternal age, pre-pregnancy obesity, pre-pregnancy comorbidities, and cesarean delivery with severe maternal morbidity, and (2) whether changes in the prevalence of these risk factors affected the trend of severe maternal morbidity.

methodsThis population-based cohort study used linked birth record and patient discharge data from live births in California during 2007-2014 (n = 3,556,206). We used multivariable logistic regression models to assess the association of advanced maternal age (≥35 years), pre-pregnancy obesity (body mass index ≥30 kg/m

resultsThe prevalence of severe maternal morbidity increased by 65% during 2007-2014. Advanced maternal age, pre-pregnancy obesity, and pre-pregnancy comorbidity also increased during this period, but cesarean delivery did not. None of these risk factors affected the increasing trend of severe maternal morbidity. However, the pre-pregnancy risk factors together were estimated to contribute to 13% (95% confidence interval: 12, 14%) of severe maternal morbidity cases in the study population overall, and cesarean delivery was estimated to contribute to 37% (95% confidence interval: 36, 38%) of cases.

conclusionsPre-pregnancy health and cesarean delivery are important risk factors for severe maternal morbidity but do not explain an increasing trend of severe maternal morbidity in California during 2007-2014. Investigation of other potential contributors is needed in order to identify ways to reverse the trend of severe maternal morbidity.

Indexed as

Maternal AgeAdultAsthmaCaliforniaCesarean SectionCohort StudiesComorbidityEducational StatusFemaleGestational AgeHumansHypertensionLogistic ModelsMultivariate AnalysisObesityObstetric Labor ComplicationsCesarean sectionComorbidityMaternal ageMaternal healthObesityPregnancy complicationsSevere maternal morbidity

Identifiers

PMID30626349
PMCPMC6327483

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.