ArticleThe journal of headache and pain2019
Abnormal functional connectivity under somatosensory stimulation in migraine: a multi-frequency magnetoencephalography study.
Article in The journal of headache and pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00600717 (Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Magnetoencephalography studies in migraine and headache disorders: A systematic review.Headache · 2025Pooled it
- Altered neuromagnetic activity under visual stimuli in migraine: a multi-frequency magnetoencephalography study.Frontiers in neurology · 2025Article
- Online functional connectivity analysis of large all-to-all networks in MNE Scan.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations.International journal of molecular sciences · 2023Review
- Resting State Electrophysiological Cortical Activity: A Brain Signature Candidate for Patients with Migraine.Current pain and headache reports · 2022Review
- Altered effective connectivity in migraine patients during emotional stimuli: a multi-frequency magnetoencephalography study.The journal of headache and pain · 2022Article
- Altered Brain Activity and Effective Connectivity within the Nonsensory Cortex during Stimulation of a Latent Myofascial Trigger Point.Neural plasticity · 2022Article
- Disconnectome of the migraine brain: a "connectopathy" model.The journal of headache and pain · 2021Article
- Nonlinear System Identification of Neural Systems from Neurophysiological Signals.Neuroscience · 2021Review
- Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference.Brain sciences · 2021Review
- Thalamocortical Connectivity in Experimentally-Induced Migraine Attacks: A Pilot Study.Brain sciences · 2021Article
- Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective.Frontiers in psychiatry · 2021Review
- Role of High Frequency Oscillations of Somatosensory Evoked Potentials in Deciphering Pathophysiology of Migraine.Journal of neurosciences in rural practice · 2021Article
- Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura.Frontiers in neurology · 2019Article
- Cortical mechanisms in migraine.Molecular painArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAlthough altered neural networks have been demonstrated in recent MEG (magnetoencephalography) research in migraine patients during resting state, it is unknown whether this alteration can be detected in task-related networks. The present study aimed to investigate the abnormalities of the frequency-specific somatosensory-related network in migraine patients by using MEG.
methodsTwenty-two migraineurs in the interictal phase and twenty-two sex- and age-matched healthy volunteers were studied using a whole-head magnetoencephalography (MEG) system. Electrical stimuli were delivered alternately to the median nerve on the right wrists of all subjects. MEG data were analyzed in a frequency range of 1-1000 Hz in multiple bands.
resultsThe brain network patterns revealed that the patients with migraine exhibited remarkably increased functional connectivity in the high-frequency (250-1000 Hz) band between the sensory cortex and the frontal lobe. The results of quantitative analysis of graph theory showed that the patients had (1) an increased degree of connectivity in the theta (4-8 Hz), beta (13-30 Hz) and gamma (30-80 Hz) bands; (2) an increased connectivity strength in the beta (13-30 Hz) and gamma (30-80 Hz) bands; (3) an increased path length in the beta (13-30 Hz), gamma (30-80 Hz) and ripple (80-250 Hz) bands; and (4) an increased clustering coefficient in the theta (4-8 Hz), beta (13-30 Hz) and gamma (30-80 Hz) bands.
conclusionsThe results indicate that migraine is associated with aberrant connections from the somatosensory cortex to the frontal lobe. The frequency-specific increases in connectivity in terms of strength, path length and clustering coefficients support the notion that migraineurs have elevated cortical networks. This alteration in functional connectivity may be involved in somatosensory processing in migraine patients and may contribute to understanding migraine pathophysiology and to providing convincing evidence for a spatially targeted migraine therapy.
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