Evidence map›Paper›PMID 30626284›Full record

ArticleAutophagy2019

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.

Erinna F Lee, Nicholas A Smith, Tatiana P Soares da Costa, Nastaran Meftahi, Shenggen Yao, Tiffany J Harris, Sharon Tran, Anne Pettikiriarachchi, Matthew A Perugini, David W Keizer and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Targeting p53 pathways: mechanisms, structures, and advances in therapy.Signal transduction and targeted therapy · 2023
    Pooled it
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  11. Effects ofInfection and immunity · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Erinna F Leea La Trobe Institute for Molecular Science , La Trobe University , Melbourne , Australia.
Nicholas A Smitha La Trobe Institute for Molecular Science , La Trobe University , Melbourne , Australia.
Tatiana P Soares da Costaa La Trobe Institute for Molecular Science , La Trobe University , Melbourne , Australia.
Nastaran Meftahia La Trobe Institute for Molecular Science , La Trobe University , Melbourne , Australia.
Shenggen Yaod Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , Parkville , Australia.
Tiffany J Harrisb Cell Death and Survival Group , Olivia Newton-John Cancer Research Institute , Heidelberg , Australia.
Sharon Tranb Cell Death and Survival Group , Olivia Newton-John Cancer Research Institute , Heidelberg , Australia.
Anne Pettikiriarachchie Structural Biology Division , The Walter and Eliza Hall Institute of Medical Research , Parkville , Australia.
Matthew A Peruginia La Trobe Institute for Molecular Science , La Trobe University , Melbourne , Australia.
David W Keizerd Bio21 Molecular Science and Biotechnology Institute , The University of Melbourne , Parkville , Australia.
Marco Evangelistab Cell Death and Survival Group , Olivia Newton-John Cancer Research Institute , Heidelberg , Australia.
Brian J Smitha La Trobe Institute for Molecular Science , La Trobe University , Melbourne , Australia.
W Douglas Fairliea La Trobe Institute for Molecular Science , La Trobe University , Melbourne , Australia.
La Trobe University · AUOlivia Newton-John Cancer Wellness & Research Centre · AUUniversity of Melbourne · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BECN1/Beclin 1 is a critical protein in the initiation of autophagosome formation. Recent studies have shown that phosphorylation of BECN1 by STK4/MST1 at threonine 108 (T108) within its BH3 domain blocks macroautophagy/autophagy by increasing BECN1 affinity for its negative regulators, the anti-apoptotic proteins BCL2/Bcl-2 and BCL2L1/Bcl-x

Indexed as

Protein Interaction Domains and MotifsAutophagyBeclin-1Cell SurvivalCrystallography, X-RayHippo KinasesHumansIntracellular Signaling Peptides and ProteinsModels, MolecularMolecular Dynamics SimulationPhosphorylationProtein BindingProtein Interaction MappingProtein Processing, Post-TranslationalProtein Serine-Threonine KinasesProtein Structure, QuaternaryBCL2 protein, humanBeclin-1BECN1 protein, humanHippo KinasesIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-bcl-2STK4 protein, humanAutophagyBCL2/Bcl-2BCL2L1/Bcl-xBECN1/Beclin1BH3 domainSTK4/MST1

Identifiers

PMID30626284
PMCPMC6526822
OpenAlexW2906682542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.