Evidence map›Paper›PMID 30626099›Full record

ReviewVaccines2019

Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection.

Mariana Guerra-Maupome, Mitchell V Palmer, Jodi L McGill, Randy E Sacco

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Pathological and molecular findings associated with BRSV in cattle and buffaloes with pulmonary disease.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
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  7. Identification of a DRB3*011:01-restricted CD4Frontiers in immunology · 2023
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mariana Guerra-MaupomeDepartment of Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, IA 50011, USA. marianag@iastate.edu.
Mitchell V PalmerInfectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA. mitchell.palmer@ars.usda.gov.
Jodi L McGillDepartment of Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, IA 50011, USA. jlmcgill@iastate.edu.
Randy E SaccoRuminant Diseases and Immunology Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA. randy.sacco@ars.usda.gov.ORCID 0000-0002-1492-5763
Agricultural Research Service · USIowa State University · US

Funding

Determining the role of Interleukin-17 in the Immune Response to Respiratory Syncytial Virus InfectionR21AI127895 · NIAID · KANSAS STATE UNIVERSITY · PI MCGILL, JODI · 2017 to 2018
$420k
NIAID NIH HHS R21 AI127895NIH HHS AI121729
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a significant cause of pediatric respiratory tract infections. It is estimated that two-thirds of infants are infected with RSV during the first year of life and it is one of the leading causes of death in this age group worldwide. Similarly, bovine RSV is a primary viral pathogen in cases of pneumonia in young calves and plays a significant role in bovine respiratory disease complex. Importantly, naturally occurring infection of calves with bovine RSV shares many features in common with human RSV infection. Herein, we update our current understanding of RSV infection in cattle, with particular focus on similarities between the calf and human infection, and the recent reports in which the neonatal calf has been employed for the development and testing of vaccines and therapeutics which may be applied to hRSV infection in humans.

Indexed as

calf modelhumanRSVtherapeuticsvaccines

Identifiers

PMID30626099
PMCPMC6466205
OpenAlexW2909655466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.