ArticleInsects2019
Compound and Dose-Dependent Effects of Two Neonicotinoid Pesticides on Honey Bee (
Article in Insects, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed.
- Neonicotinoid Residues in Tea Products from China: Contamination Patterns and Implications for Human Exposure.Toxics · 2025Article
- Honey bee immune response to trace concentrations of clothianidin goes beyond the macronutrients found in artificial diets.Scientific reports · 2025Article
- Reduced Honeybee Pollen Foraging under Neonicotinoid Exposure: Exploring Reproducible Individual and Colony Level Effects in the Field Using AI and Simulation.Environmental science & technology · 2025Article
- Exposure of Apis mellifera (Hymenoptera: Apidae) colonies to imidacloprid impairs larval development, promotes oxidative stress in pupae, and induces changes in the midgut of adult bees.Biological research · 2025Article
- The Altered Lipid Composition and Key Lipid Metabolic Enzymes in Thiacloprid-ResistantInternational journal of molecular sciences · 2024Article
- Honeybee gut bacterial strain improved survival and gut microbiota homeostasis inMicrobiology spectrum · 2024Article
- Article
- The Insecticide Imidacloprid DecreasesInsects · 2022Article
- Nutritional stress exacerbates impact of a novel insecticide on solitary bees' behaviour, reproduction and survival.Proceedings. Biological sciences · 2022Article
- Dietary Contamination with a Neonicotinoid (Clothianidin) Gradient Triggers Specific Dysbiosis Signatures of Microbiota Activity along the Honeybee (Microorganisms · 2021Article
- Neonicotinoid pesticides exert metabolic effects on avian pollinators.Scientific reports · 2021Article
- Missing Nurse Bees-Early Transcriptomic Switch From Nurse Bee to Forager Induced by Sublethal Imidacloprid.Frontiers in genetics · 2021Article
- Diverging landscape impacts on macronutrient status despite overlapping diets in managed (Conservation physiology · 2020Article
- Article
- Acetylcholine and Its Receptors in Honeybees: Involvement in Development and Impairments by Neonicotinoids.Insects · 2019Review
- Special Issue: Honey Bee Research in the US: Current State and Solutions to Beekeeping Problems.Insects · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Use of neonicotinoid pesticides is now ubiquitous, and consequently non-targeted arthropods are exposed to their residues at sub-lethal doses. Exposure to these neurotoxins may be a major contributor to poor honey bee colony health. Few studies have explored how sub lethal exposure to neonicotinoids affects honey bee metabolic physiology, including nutritional and energetic homeostasis, both of which are important for maintaining colony health. Reported here are results from a study of chronic oral exposure of honey bees to two sub lethal concentrations of clothianidin and imidacloprid. Neonicotinoids altered important aspects of honey bee nutritional and metabolic physiology in a compound and dose-dependent manner; both compounds at low doses reduced honey bee body weight. Low-dose clothianidin exposure resulted in bees having protein, lipids, carbohydrates, and glycogen levels similar to newly emerged bees. High-dose clothianidin exposure lowered lipids and glycogen content of bees. High-dose imidacloprid exposure resulted in bees having depressed metabolic rate. Low-dose imidacloprid exposure resulted in bees consuming low and high levels of protein and carbohydrate rich foods, respectively. Results suggest neonicotinoids interfere with honey bee endocrine neurophysiological pathways. Compound and dose-dependent effects might represent respective chemical structural differences determining an observed effect, and thresholds of compound effects on honey bee physiology.
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Registered trials
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