Evidence map›Paper›PMID 30625379›Full record

Observational studyPapillomavirus research (Amsterdam, Netherlands)2019

Dynamics of genotype-specific HPV clearance and reinfection in rural Ghana may compromise HPV screening approaches.

Amrei Krings, Gifty Boateng, Priscilla Dunyo, Joseph E Amuah, Rashid A Adams, Lois Adunyame, Dinah O Nkansah, Comfort M Wormenor, Benjamin T Hansen, Isaac Gedzah and 3 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Papillomavirus research (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Amrei KringsClinic for Gynecology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany. Electronic address: amrei.krings@charite.de.
Gifty BoatengNational Public Health and Reference Laboratory, Korle Bu, Accra, Ghana.
Priscilla DunyoCatholic Hospital Battor, Volta Region, Ghana.
Joseph E AmuahSchool of Epidemiology & Public Health, University of Ottawa, Canada.
Rashid A AdamsSchool of Biomedical and Allied Health Sciences, University of Ghana College of Health Sciences, Korle Bu, Accra, Ghana. Electronic address: raadams@chs.edu.gh.
Lois AdunyameSchool of Biomedical and Allied Health Sciences, University of Ghana College of Health Sciences, Korle Bu, Accra, Ghana.
Dinah O NkansahSchool of Biomedical and Allied Health Sciences, University of Ghana College of Health Sciences, Korle Bu, Accra, Ghana.
Comfort M WormenorCatholic Hospital Battor, Volta Region, Ghana.
Benjamin T HansenCatholic Hospital Battor, Volta Region, Ghana.
Isaac GedzahCatholic Hospital Battor, Volta Region, Ghana.
Richard H AsmahSchool of Biomedical and Allied Health Sciences, University of Ghana College of Health Sciences, Korle Bu, Accra, Ghana. Electronic address: rhasmah@chs.edu.gh.
Edwin K WireduSchool of Biomedical and Allied Health Sciences, University of Ghana College of Health Sciences, Korle Bu, Accra, Ghana. Electronic address: ekwiredu@chs.edu.gh.
Andreas M KaufmannClinic for Gynecology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany. Electronic address: andreas.kaufmann@charite.de.
Catholic University College of Ghana · GHUniversity of Health and Allied Sciences · GHUniversity of Ghana · GHCharité - Universitätsmedizin Berlin · DEFreie Universität Berlin · DEKorle Bu Teaching Hospital · GHUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent Human Papillomavirus (HPV) infection is a prerequisite for cervical cancer development. Few studies investigated clearance of high-risk HPV in low-and-middle-income countries. Our study investigated HPV clearance and persistence over four years in women from North Tongu District, Ghana. In 2010/2011, cervical swabs of 500 patients were collected and HPV genotyped (nested multiplex PCR) in Accra, Ghana. In 2014, 104 women who previously tested positive for high-risk HPV and remained untreated were re-tested for HPV. Cytobrush samples were genotyped (GP5+/6+ PCR & Luminex-MPG readout) in Berlin, Germany. Positively tested patients underwent colposcopy and treatment if indicated. Of 104 women, who tested high-risk HPV+ in 2010/2011, seven (6,7%; 95%CI: 2.7-13.4%) had ≥1 persistent high-risk-infection after ~4 years (mean age 39 years). Ninety-seven (93,3%; 95%CI: 86.6-97.3%) had cleared the original infection, while 22 (21.2%; 95%CI: 13.8-30.3%) had acquired new high-risk infections with other genotypes. Persistent types found were HPV 16, 18, 35, 39, 51, 52, 58, and 68. Among those patients, one case of CIN2 (HPV 68) and one micro-invasive cervical cancer (HPV 16) were detected. This longitudinal observational data suggest that single HPV screening rounds may lead to over-referral. Including type-specific HPV re-testing or additional triage methods could help reduce follow-up rates.

Indexed as

GenotypeRural PopulationAdultAgedAged, 80 and overColposcopyEarly Detection of CancerFemaleGenotyping TechniquesGhanaHumansLongitudinal StudiesMiddle AgedPapillomaviridaePapillomavirus InfectionsYoung AdultCervical screeningHPV screeningLMICNatural historyPersistence

Identifiers

PMID30625379
PMCPMC6350109
OpenAlexW2907748369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.